Results 21 to 30 of about 28,180 (235)

Inhibition of glioma cell viability by jatrophone via NF-κB down-regulation and apoptosis inhibitor up-regulation

Archives of Medical Science, 2020
Introduction The present study evaluated the pro-survival signaling pathway inhibition potential of jatrophone in glioblastoma cells with the intention to develop effective treatment for glioblastoma.
Lei Yuan, Fei Wang, Ting Zhang, Yiming Zhang, Hong Pan, Guoguang Lv, Baozhong Zhang   +6 more
doaj   +1 more source

Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities

Molecules, 2022
Six new diterpenoids, blusamiferoids A–F (1–6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera.
Xiao-Ling Huang, Dai-Wei Wang, Ying-Qian Liu, Yong-Xian Cheng   +3 more
doaj   +1 more source

Age-Dependent Decrease in Hepatic Geranylgeranoic Acid Content in C3H/HeN Mice and Its Oral Supplementation Prevents Spontaneous Hepatoma

Metabolites, 2021
Geranylgeranoic acid (GGA) has been developed as a preventive agent against second primary hepatoma. Recently, GGA was reported to induce cell death in human hepatoma cells via TLR4-mediated pyroptosis.
Yuki Tabata, Masahide Omori, Yoshihiro Shidoji   +2 more
doaj   +1 more source

Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities

Molecules, 2017
Two new dihydrochalcone enantiomers (+)-1 and (−)-1, along with eight known compounds 3–10, were obtained from Pteris ensiformis. The planar structures were determined on the basis of extensive 1D and 2DNMR and HRESIMS.
Yu-Sheng Shi, Yan Zhang, Wen-Zhong Hu, Xiu-Fu Zhang, Xin Fu, Xia Lv   +5 more
doaj   +1 more source

Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. [PDF]

, 2015
Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), is characterized by CNS demyelination mediated by autoreactive T cells.
Deng, Wenbin, Fan, Xiaohang, Liu, Wenwei, Xiao, Juan, Yang, Lin, Yang, Rongbing   +5 more
core   +2 more sources

Fosbergenone: 3-[2-(1,2,5,5-Tetramethyl-7-oxo-1,2,3,4,4a,5,6,7-octahydronaphthalen-1-yl)ethyl]-2,5-dihydrofuran-2-one

Molbank, 2022
A new ent-halimane diterpenoid, fosbergenone (1) was isolated from the foliar bud exudate of Gardenia fosbergii. The structure of 1 was elucidated based on spectroscopic data including IR, 1D and 2D NMR, as well as high-resolution mass spectrometry.
Joy Ebenezer Rajakulendran, Emmanuel T. Oluwabusola, Rainer Ebel, Marcel Jaspars   +3 more
doaj   +1 more source

Undescribed Metabolites from an Actinobacteria Acrocarpospora punica and Their Anti-Inflammatory Activity

Molecules, 2022
In an effort to explore bioactive anti-inflammatory compounds from natural Actinobacteria resources from all over Taiwan and various ecological environments, an active strain of Acrocarpospora punica was collected at Taitung County in Taiwan, prepared ...
Ming-Der Wu, Ming-Jen Cheng
doaj   +1 more source

An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae [PDF]

, 2017
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide.
Azevedo, Vasco A.C., Barh, Debmalya, Baumbach, Jan, Benevides, Leandro de Jesus, Costa, Daniela Arruda, Ghosh, Preetam, Hassan, Syed Shah, Jamal, Syed Babar, Röttger, Richard, Silva, Artur, Tiwari, Sandeep, Turjanski, Adrián G., Ullah, Asad, Viana, Marcus V.   +13 more
core   +6 more sources

Diterpenoids from the aerial parts of Isodon macrocalyx

Guangxi Zhiwu, 2023
To study the constituents of Isodon macrocalyx, thirteen diterpenoids were isolated and purified from the aerial parts of I. macrocalyx by means of various column chromatographic techniques, including silica gel, ODS, Sephadex LH-20 and RP-C18 pre-HPLC ...
Yanling CHANG, Xiaoqin LIANG, Yan HUANG, Liwei PAN, Ping HOU, Chenyang REN, Jun LI   +6 more
doaj   +1 more source

Molecular Docking and Dynamic Diterpenoid-Stevia Compounds from Water Maceration-Sonification Extract as Amylase and Glucosidase Enzyme Inhibits [PDF]

Brazilian Archives of Biology and Technology
Stevia (Stevia rebaudiana), with its intense sweetness, therapeutic properties, and safety profile, serves not only as a sugar substitute but also promotes holistic metabolic health.
Sentot Joko Raharjo, Teti Estiasih, Ernanin Dyah Wijayanti, Dewi Ratih Tirto Sari, Yantty Maryanty   +4 more
doaj   +1 more source