Results 151 to 160 of about 271,886 (306)

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Ein Dithio‐Vinylthio‐C2‐Synthon, das kristalline und lumineszierende, schwefelhaltige Polymere ermöglicht

Angewandte Chemie, EarlyView.
Die Umsetzung von CaC2 zu einem modularen C2‐Baustein ermöglicht die Synthese eines α,ω‐Bis(vinylthio)‐Monomers sowie dessen Weiterumsetzung zu kristallinen, sequenzdefinierten, schwefelfunktionalisierten Polymere. Dichte Thioether‐Cluster induzieren nichtkonventionelle Lumineszenz und ermöglichen eine präzise Kontrolle der Struktur‐Eigenschafts ...
Bercis Pektas, Cuong M. Q. Le, Samar Hajjar‐Garreau, Simon Gree, Hatice Mutlu   +4 more
wiley   +1 more source

A Dithio Vinylthio C2 Synthon Enabling Crystalline and Luminescent Sulfur‐Decorated Polymers

Angewandte Chemie International Edition, EarlyView.
Transforming CaC2 into a modular C2 building block enables the synthesis of α,ω‐bis(vinylthio) monomer and its conversion into crystalline, sequence‐defined sulfur‐decorated polymers. Their dense thioether clustering induces nonconventional luminescence and provides structure–function control in a more‐sustainable polymer platform.
Bercis Pektas, Cuong M. Q. Le, Samar Hajjar‐Garreau, Simon Gree, Hatice Mutlu   +4 more
wiley   +1 more source

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, EarlyView.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

Dithiothreitol induced endoplasmic reticulum stress and its role in neurodegeneration in <i>Caenorhabditis elegans</i>. [PDF]

World J Biol Chem
Raj G, Kumar M, Shreya S, Bhardwaj S, Priya R, Mangalhara KC, Jain BP.   +6 more
europepmc   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Impact of Reducing Agents on Protein Synthesis in a Reconstituted Cell-Free Protein Synthesis System. [PDF]

ACS Synth Biol
Fuse-Murakami T, Terazawa S, Gondhalekar R, Ito S, Miyawaki S, Mizukami Y, Salgado WP, Yang Z, Fujishima K, Kanamori T.   +9 more
europepmc   +1 more source

Soil Sulfur and Nitrogen Affect Wheat Flour Mixing Characteristics and Protein Features in Flour and Dough

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Sulfur and nitrogen affect wheat yield and the protein content and quality. Hard red spring wheat (Albany cultivar) grown under six different soil nitrate application levels (0, 60, 120, 180, 240, and 300 lbs/acre) and two sulfur levels (0 or 20 lbs/acre) was used.
E. T. Quayson, G. A. Annor, D. Kaiser, P.‐N. T. Johnson   +3 more
wiley   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source