Results 181 to 190 of about 270,943 (291)

Single‐Cell Nanodroplet Processing Proteomics Pipeline for Analysis of Human‐Derived Microglia

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Single‐cell omics tools provide unique insights into heterogeneous cell populations and their responses to stimuli. For example, single‐cell RNA sequencing has identified several transcriptionally distinct populations of microglia, which are resident immune cells of the central nervous system (CNS) that are responsive to CNS injury, infection,
Ashley N. Ives   +7 more
wiley   +1 more source

Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk   +4 more
wiley   +1 more source

Mass Spectrometry Proteomics of the Nanoparticle Corona Is Highly Dependent on Sample Preparation Protocol

open access: yesPROTEOMICS, EarlyView.
ABSTRACT It is widely established that the layers of proteins bound to the surface of nanoparticles (NPs), also known as the protein corona, critically influence their behavior in biological environments. Despite numerous proteomics studies performed in different NP‐corona systems, the impact of proteomic sample preparation methods on corona profiling ...
Asia Saorin   +4 more
wiley   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae   +6 more
wiley   +1 more source

SYN‐A, a naturally derived synergist, restores pyrethroid efficacy against cabbage stem flea beetle but negatively impacts its parasitoid Microctonus brassicae

open access: yesPest Management Science, EarlyView.
SYN‐A, a naturally derived synergist, inhibited key metabolic pathways associated with pyrethroid insecticide resistance in cabbage stem flea beetle (CSFB) and its parasitoid Microctonus brassicae. SYN‐A restored pyrethroid efficacy against resistant CSFB allowing up to 80% reduction in application rates.
Patricia A. Ortega‐Ramos   +2 more
wiley   +1 more source

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