Results 61 to 70 of about 270,943 (291)

Staphylococcus aureus Detection in Milk Using a Thickness Shear Mode Acoustic Aptasensor with an Antifouling Probe Linker

Biosensors, 2023
Contamination of food by pathogens can pose a serious risk to health. Therefore, monitoring for the presence of pathogens is critical to identify and regulate microbiological contamination of food.
Sandro Spagnolo, Katharina Davoudian, Brian De La Franier, Tibor Hianik, Michael Thompson   +4 more
doaj   +1 more source

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain [PDF]

, 2013
Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the ...
Fischer, Fabian, Hamann, Andrea, Osiewacz, Heinz D., Weil, Andrea   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effects of Dithiothreitol on Fertilization and Early Development in Sea Urchin

Cells, 2021
The vitelline layer (VL) of a sea urchin egg is an intricate meshwork of glycoproteins that intimately ensheathes the plasma membrane. During fertilization, the VL plays important roles. Firstly, the receptors for sperm reside on the VL.
Nunzia Limatola, Jong Tai Chun, Sawsen Cherraben, Jean-Louis Schmitt, Jean-Marie Lehn, Luigia Santella   +5 more
doaj   +1 more source

The Acidic Tail of the Cdc34 Ubiquitin-conjugating Enzyme Functions in Both Binding to and Catalysis with Ubiquitin Ligase SCFC^(dc4*) [PDF]

, 2009
Ubiquitin ligases, together with their cognate ubiquitin-conjugating enzymes, are responsible for the ubiquitylation of proteins, a process that regulates a myriad of eukaryotic cellular functions. The first cullin-RING ligase discovered, yeast SCF^(Cdc4)
Bing Hao, Block, Cardozo, Creighton, Dane A. Mohl, Das, Deshaies, Dye, Eletr, Feldman, Frescas, Gary Kleiger, Gill, Gill, Hershko, Hofmann, Kamura, Kleiger, Kolman, Koppenol, Li, Li, Mathias, Nakayama, Ohta, Pan, Petroski, Petroski, Petroski, Pohl, Raymond J. Deshaies, Ruiz, Saha, Schoppink, Schreiber, Schreiber, Schwob, Seol, Silver, Skowyra, Skowyra, Tan, Thrower, Van Loon, Willems, Wu, Xie, Yang, Zheng   +48 more
core   +3 more sources

Dithiothreitol Enhances Listeria monocytogenes Mediated Cell Cytotoxicity [PDF]

Microbiology and Immunology, 2000
AbstractThe hybridoma Ped‐2E9 based cytotoxicity assay was developed to distinguish virulent from avirulent Listeria species in 6 hr. The cytotoxicity effect on Ped‐2E9 was reported to be primarily due the cytolytic action of listeriolysin O (LLO), produced by L. monocytogenes. In this study, the effect of a reducing agent, dithiothreitol (DTT, 0–2 mm)
D G, Westbrook, A K, Bhunia
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Reducing Agent Dithiothreitol Modulates the Ventilatory Responses That Occur in Freely Moving Rats during and following a Hypoxic–Hypercapnic Challenge

Antioxidants
The present study examined the hypothesis that changes in the oxidation–reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic–hypercapnic ...
Paulina M. Getsy, Gregory A. Coffee, Walter J. May, Santhosh M. Baby, James N. Bates, Stephen J. Lewis   +5 more
doaj   +1 more source

Cloning, expression and antioxidant activity of a thioredoxin peroxidase from Branchiostoma belcheri tsingtaunese. [PDF]

PLoS ONE, 2017
Peroxiredoxins (Prxs) are ubiquitous antioxidant enzymes that catalyze the thioredoxin- dependent reduction of hydroperoxides. In this study, a novel thioredoxin peroxidase (Bbt-TPx1), a member of the peroxiredoxin superfamily, was found by EST sequence ...
Jian Liao, Kaiyu Wang, Weirong Yao, Xunfei Yi, Huihui Yan, Min Chen, Xiaopeng Lan   +6 more
doaj   +1 more source

Dithiothreitol Affects the Fertilization Response in Immature and Maturing Starfish Oocytes

Biomolecules, 2023
Immature starfish oocytes isolated from the ovary are susceptible to polyspermy due to the structural organization of the vitelline layer covering the oocyte plasma membrane, as well as the distribution and biochemical properties of the actin ...
Nunzia Limatola, Jong Tai Chun, Kazuyoshi Chiba, Luigia Santella   +3 more
doaj   +1 more source