Results 61 to 70 of about 54,561 (294)

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Diurnal cycle of precipitable water vapor over Spain [PDF]

, 2011
Knowledge of the diurnal cycle of precipitable water vapor (PWV) is very limited owing to the lack of data with sufficient temporal resolution. Currently, GPS receivers have proven to be a suitable technique to determine PWV diurnal variations.
Laulainen, Nels, Toledano, Carlos, Bennouna, Yasmine, Cachorro, Victoria E., Frutos Baraja, Ángel Máximo de, Ortiz de Galisteo, José Pablo, Torres, Benjamín   +6 more
core   +1 more source

Causal‐Guided Ultra‐Long‐Term Time Series Forecasting Via Anticipated Covariates

Advanced Science, EarlyView.
Often treated as unknown, information from the future remains underutilized.We demonstrate that in a coupled dynamical system, providing the future state of the effect enables accurate forecasting of the cause for a long timesteps. A time series forecasting paradigm that introduces anticipated covariates to represent such known future states is ...
Jintong Zhao, Yufei Liu, Ruixi Huang, Zhongxue Gan, Siyang Leng   +4 more
wiley   +1 more source

Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment [PDF]

Human Molecular Genetics, 2015
The circadian cycle is a genetically encoded clock that drives cellular rhythms of transcription, translation and metabolism. The circadian clock interacts with the diurnal environment that also drives transcription and metabolism during light/dark, sleep/wake, hot/cold and feast/fast daily and seasonal cycles.
Powell, Weston T, LaSalle, Janine M
openaire   +4 more sources

Wearable‐Derived Diurnal Alignment Between Physical Activity and Device Temperature Predicts Future Disease and Mortality Risk

Advanced Science, EarlyView.
Wearable‐derived diurnal alignment between physical activity and device temperature, decomposed into 24 h coupling strength (M24), phase deviation (D24), and 12 h harmonic magnitude (M12), is examined in approximately 90,000 UK Biobank participants.
Han Chen, Jiahe Wei, Jonathan Cedernaes, Christian Benedict, Athanasios Tsanas, Zhi Cao, Xiao Tan   +6 more
wiley   +1 more source

The diurnal cortisol cycle and cognitive performance in the healthy old [PDF]

, 2011
Associations between cognitive performance and cortisol have variously been reported for measures of both cortisol level and change, and for some domains of cognitive functioning more than others.
C. Fredhoi, Clow, A., Forte, D., C. Loveday, Evans, P., P.D. Evans, F. Hucklebridge, E. Aitchison, A. Clow, Fredhoi, C., Loveday, C., Hucklebridge, F., D. Forte, Aitchison, E.   +13 more
core   +1 more source

Simulation of land surface temperatures: comparison of two climate models and satellite retrievals [PDF]

Geoscientific Model Development, 2009
Recently there has been significant progress in the retrieval of land surface temperature from satellite observations. Satellite retrievals of surface temperature offer several advantages, including broad spatial coverage, and such data are potentially ...
J. M. Edwards
doaj  

The ALEX17 diurnal cycles in complex terrain benchmark

Journal of Physics: Conference Series, 2021
AbstractThe NEWA ALEX17 experiment was conducted with the objective of characterizing the wind conditions upstream of the Alaiz Test Site for the validation of flow models. From the intensive operational period, a case study has been selected for a Wakebench benchmark consisting of four consecutive days with relatively persistent winds from the North ...
Sanz Rodrigo, Javier, Santos, Pedro, Chávez Arroyo, R, Avila, Matias, Cavar, Dalibor, Lehmkuhl Barba, Oriol, Owen, Herbert, Li, R, Tromeur, Eric   +8 more
openaire   +2 more sources

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source