Results 91 to 100 of about 48,184 (314)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Loggerhead sea turtle (Caretta caretta) diving changes with productivity, behavioral mode, and sea surface temperature.

PLoS ONE, 2019
The relationship between dive behavior and oceanographic conditions is not well understood for marine predators, especially sea turtles. We tagged loggerhead turtles (Caretta caretta) with satellite-linked depth loggers in the Gulf of Mexico, where there
Autumn R Iverson, Ikuko Fujisaki, Margaret M Lamont, Kristen M Hart   +3 more
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

The Effects of a Training Program on Some Physiological Variables Before and After Diving in Scuba Divers [PDF]

Mağallaẗ Buḥūṯ Al-Tarbiyyaẗ Al-Badaniyyaẗ wa ʿulūm Al-Rīyāḍaẗ
The current research aimed to identify the effect of diving training programs on some physiological variables of divers, using an experimental approach on a sample selected purposively from divers in Sharm El-Sheikh city, registered with the Egyptian ...
محمد طلعت عبدالعظيم
doaj   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Swimming modes affect dive durations in diving birds

Journal of Avian Biology
Dive duration and body mass are positively correlated across air‐breathing vertebrate species, but other factors affecting dive duration are inadequately studied.
Hiroya Matsushita, Yuuki Y. Watanabe
doaj   +1 more source

Flat space, deep learning (Digital Aquarium Deep Dive)

, 2015
In this video professor Eric Mazur of Harvard University talks about a novel team-based, project-based approach to teaching that breaks the mould by giving students ownership of their learning.
Eric Mazur
core  

DiVE: First releease

, 2016
<p>A 3D interactive web viewer of large number of data points</p ...
sonja georgievska
core   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Predicting Post-Dive Inert Gas Bubble Grades in Non-Decompression Scuba Diving with Air: Simplified Model for Enhanced Diver Safety

Sports Medicine - Open
Background Even well-planned no-decompression dives can still produce inert gas bubbles that increase decompression sickness risk. A previously proposed formula for predicting post-dive bubble grades integrates individual factors (age, breathing gas ...
Andreas Fichtner, Björn Hannesen, Felix Stein, Benedikt Schrofner-Brunner, Thomas Pohl, Thomas Grab, Thea Koch, Tobias Fieback   +7 more
doaj   +1 more source