Results 201 to 210 of about 1,752,749 (259)

Ecotypic divergence in Mongolian Scots pine persists via large-effect genetic adaptation and phenotypic plasticity. [PDF]

BMC Plant Biol
Wuyuntana, Fong Q, Ke CY, Gao DM, Luo MX, Yang YZ, Gao RH, Liao PC.   +7 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Physics-constrained transformer for wind power forecasting. [PDF]

Sci Rep
Wang D, Luo Q, Gao J, Zhang D, Chen Y.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A novel <i>Eimeria</i> species found in the marbled polecat (<i>Vormela peregusna</i>). [PDF]

Int J Parasitol Parasites Wildl
Cui N, Wang Z, Zhang J, Hornok S, Zhang Y, Zhao G, Tan W, Wang Y.   +7 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Recent Lineage Split in <i>Cladium mariscus</i> Preceding the Disjunction of Two Biodiversity Hotspots: Evidence From Plastid Genomes. [PDF]

Ecol Evol
Qian XH, Yue LL.
europepmc   +1 more source

Genomic Insights Into Species Delimitation and the Evolutionary History of Mimetic <i>Aletis</i> Moths (Lepidoptera, Geometridae) in the Afrotropics. [PDF]

Ecol Evol
Lee KM, Staude H, Holm S, Laiho E, Murillo-Ramos L, Opedal ØH, Rajaei H, Terblanche RF, Botha M, Sihvonen P.   +9 more
europepmc   +1 more source

Visualization for Departures from Symmetry with the Power-Divergence-Type Measure in Square Contingency Tables. [PDF]

Psychometrika
Urasaki W, Nakagawa T, Tsuchida J, Tahata K.   +3 more
europepmc   +1 more source