Results 271 to 280 of about 1,557,512 (335)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Activity Patterns in Relation to Dynamic Functional Network States: A Longitudinal Feasibility Study of Brain-Behavior Associations in Young Adults. [PDF]

Brain Sci
Soleimani N, Misiura M, Maan A, Wiafe SL, Burnette J, Hemphill A, Dotson VM, Ellis R, King TZ, Tone EB, Calhoun VD.   +10 more
europepmc   +1 more source

If an (Endangered) Tree Falls in the Forest, and No One is Around....: Resolving the Divergence between Standing Requirements and Congressional Intent in Environmental Legislation

, 2009
Preston Carter
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Evidence of a putative new species Haemagogus 'Trinidad sp. A' from the Caribbean sharing mitogenome lineages with species endemic to the Amazon. [PDF]

Sci Rep
Ali RLMN, Singh S, Sandiford SL, Lee Y, Daniel B, Shui-Feng R, Severson DW, Ramsubhag A, Norris DE.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Discovering and protecting cryptic biodiversity: A case study of a previously undescribed, vulnerable bird species in Japan. [PDF]

PNAS Nexus
Saitoh T, Shipilina D, Xia C, Zhang L, Seki SI, Olsson U, Alström P.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Molecular mechanisms underlying early functional divergence in snake venom inferred from the genomes of two pitviper lineages. [PDF]

BMC Biol
Mason AJ, Nachtigall PG, Rokyta DR, Parkinson CL, Grazziotin FG, Junqueira-de-Azevedo ILM, Gibbs HL.   +6 more
europepmc   +1 more source