Results 81 to 90 of about 325,578 (303)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Investigating Eusociality in Bees while Trusting the Uncertainty

open access: yesSociobiology, 2014
Phylogenetic hypotheses and estimates of divergence times have already been used to investigate the evolution of social behavior in all lineages of bees. The interpretation of the number of origins of eusocial behavior and the timing these events depends
Eduardo A. B. Almeida, Diego Sasso Porto
doaj   +1 more source

Divergence-time estimates for hominins provide insight into encephalization and body mass trends in human evolution: Data and Code

open access: yes, 2021
These are the code and files necessary to replicate the study "Divergence-time estimates for hominins provide insight into encephalization and body mass trends in human evolution" by Hans P. Püschel, Ornella C. Bertrand, Joseph E.
Thomas A. Püschel   +10 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Comparative Mitogenomics of Pedetontus and Pedetontinus (Insecta: Archaeognatha) Unveils Phylogeny, Divergence History, and Adaptive Evolution

open access: yesInsects
Archaeognatha is phylogenetically positioned as the basal lineage relative to all extant insect orders and comprises approximately 600 described species.
Wei Cen   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Time-calibrated phylogeny for phlebotomine sand flies based on the Fossilized Birth-Death process and the inclusion of divergence time estimation of each node, considering the Maximum Clade Credibility (MCC) tree.

open access: yes, 2023
Time-calibrated phylogeny for phlebotomine sand flies based on the Fossilized Birth-Death process and the inclusion of divergence time estimation of each node, considering the Maximum Clade Credibility (MCC) tree.
Jesús A. Díaz-Cruz (16469351)   +10 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

TimeTree: A Resource for Timelines, Timetrees, and Divergence Times [PDF]

open access: yesMolecular Biology and Evolution, 2017
Evolutionary information on species divergence times is fundamental to studies of biodiversity, development, and disease. Molecular dating has enhanced our understanding of the temporal patterns of species divergences over the last five decades, and the number of studies is increasing quickly due to an exponential growth in the available collection of ...
Sudhir, Kumar   +3 more
openaire   +2 more sources

Bayesian Divergence-Time Estimation Lecture

open access: yes, 2019
A lecture on Bayesian divergence-time estimation by Tracy A. Heath (http://phyloworks.org/).Some content is from other authors and credited where necessary.This lecture is given at various workshops on molecular evolution and phylogenetics.
Tracy Heath (98915)
core   +1 more source

Home - About - Disclaimer - Privacy