Results 71 to 80 of about 1,799,419 (221)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The generation and consequences of N-terminal proteoform diversity

Cell Reports
Summary: N-terminal proteoforms are protein variants with altered N termini that arise from RNA-driven processes, such as alternative promoter usage, splicing, and translation initiation site usage, as well as protein alterations, such as N-terminal ...
Evan J. Morrison, Olivia S. Rissland
doaj   +1 more source

Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

Frontiers in Microbiology, 2012
Many viruses, including the clinically relevant RNA viruses HIV and HCV, exist in large populations and display high genetic heterogeneity within and between infected hosts.
Niko eBeerenwinkel, Niko eBeerenwinkel, Huldrych F. Günthard, Volker eRoth, Karin J. Metzner   +4 more
doaj   +1 more source

Narratives of Diversity in the Corporate Boardroom: What Corporate Insiders Say About Why Diversity Matters [PDF]

, 2010
Over the last generation, the concept of diversity has become commonplace and taken-for-granted in discourses ranging from law to education to business. In higher education, for example, it is hard to imagine a faculty job search or a student admissions ...
Broome, Lissa Lamkin, Conley, John M., Krawiec, Kimberly D.   +2 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Improved Few-Shot SAR Image Generation by Enhancing Diversity

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Due to their remarkable capabilities of generation, deep-learning-based (DL) generative models have been widely applied in the field of synthetic aperture radar (SAR) image synthesis. This kind of data-driven DL methods usually requires abundant training
Jianghan Bao, Wen Ming Yu, Kaiqiao Yang, Che Liu, Tie Jun Cui   +4 more
doaj   +1 more source

Diversity-Oriented Synthesis and Chemoinformatic Analysis of the Molecular Diversity of sp3-Rich Morpholine Peptidomimetics

Frontiers in Chemistry, 2018
Diversity-Oriented Synthesis (DOS) consists of generating structurally diverse compounds from a complexity-generating reaction followed by cyclization steps and appendage diversity.
Elena Lenci, Riccardo Innocenti, Gloria Menchi, Andrea Trabocchi   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Next-generation sequencing reveals significant bacterial diversity of botrytized wine. [PDF]

PLoS ONE, 2012
While wine fermentation has long been known to involve complex microbial communities, the composition and role of bacteria other than a select set of lactic acid bacteria (LAB) has often been assumed either negligible or detrimental. This study served as
Nicholas A Bokulich, C M Lucy Joseph, Greg Allen, Andrew K Benson, David A Mills   +4 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source