Results 51 to 60 of about 753,108 (352)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Anti-discrimination and diversity at school. Findings from the evaluation of an organizational implementation process

Cambio, 2021
Current diversity and anti-discrimination policies are the result of intended and non-intended long-term social movements and changes. This implicates informalisation processes as well as formalisation processes of organizations, in which sexism, racism,
Stefanie Ernst
doaj   +1 more source

The Politics of Diversity in Music Education

, 2021
This open access book examines the political structures and processes that frame and produce understandings of diversity in and through music education. Recent surges in nationalist, fundamentalist, protectionist and separatist tendencies highlight the imperative for music education to extend beyond nominal policy agendas or wholly celebratory ...
Kallio, Alexis Anja, Westerlund, Heidi, Karlsen, Sidsel, Marsh, Kathryn, Sæther, Eva   +4 more
openaire   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The Hoax Phenomenon in Indonesian Society: Observing Anti-Diversity Memes since 2014

Humaniora, 2018
This article seeks to explain whether anti-diversity hoaxes that become viral on mass media disrupt the institutional memory of kebhinekaan (diversity) in Indonesian society.
Aprinus Salam
doaj   +1 more source

Building an All-In Nation: A View from the American Public [PDF]

, 2013
As shown throughout this report, Americans are much more open to diversity and more supportive of steps to reduce racial inequalities than is commonly portrayed in politics and the media.
Adrian Pantoja, John Halpin, Matt Barreto, Ruy Teixieira   +3 more
core  

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Transcendence over Diversity: black women in the academy [PDF]

, 2006
Universities, like many major public institutions have embraced the notion of ‘diversity’ virtually uncritically- it is seen as a moral ‘good in itself’.
Ahmed S., Ahmed S., Back L., Bhavnani R., Blanden J., Brah A., Brah A., Carter J., Casey K., Castells M., Collins P.H., Collins P.H., Connor H., Equality Challenge Unit (ECU) &, Fraser N., Freire P., Hall S., Hall S., Higher Education Funding Council for England (HEFCE), Hooks B., Hooks B., Housee S., Law I., Lopez I.H., Metcalf H., Mirza H.S., Mirza H.S., Mirza H.S., Mirza H.S., Mirza H.S., Modood T., Mohanty C.T., Morrison T., National Audit Office (NAO), Office Cabinet, Puwar N., Razack S., Reay D., Schneider-Ross, Simmonds F., Society Fawcett, Spivak G., Williams P.J., Women &, Young R.J.C.   +44 more
core   +2 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

The Increasing Diversity of America\u27s Youth [PDF]

, 2014
This brief documents how unfolding demographic forces have placed today’s children and youth at the forefront of America’s new racial and ethnic diversity. Authors Kenneth M. Johnson, Andrew Schaefer, Daniel T. Lichter, and Luke T. Rogers discuss how the
Johnson, Kenneth M., Lichter, Daniel T., Rogers, Luke T., Schaefer, Andrew P.   +3 more
core   +1 more source