Results 91 to 100 of about 39,641 (298)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Effects of N/Ne impurity seeding on the divertor asymmetry in HL-2A tokamak

Nuclear Fusion
Divertor asymmetry is a major challenge in achieving high-power, long-pulse discharges in future fusion reactors. Impurity seeding is the most common method for achieving divertor detachment in fusion devices.
Qingyi Tan, Haoran Ye, Xueyu Gong, Yijun Zhong, Qianhong Huang, Zhe Wang, Chengzhi Cao, Zhanhui Wang, Cailong Fu, Min Xu, Tao Yang   +10 more
doaj   +1 more source

The effect of ionization on the populations of excited levels of C IV and C V in tokamak edge plasmas

, 2013
The main populating and depopulating mechanisms of the excited energy levels of ions in plasmas with densities
Aggarwal, K M, Coffey, I H, Contributors, JET-EFDA, Keenan, F P, Lawson, K D   +4 more
core   +1 more source

Flow diverters for the posterior inferior cerebellar artery aneurysms: A systematic review and a single-arm meta-analysis

, 2021
Xiang Liu, Kunyang Bao, Wenzhang Luo, Weifeng Wan, Tangming Peng, Changren Huang   +5 more
openalex   +2 more sources

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Divertor heat flux mitigation by using supersonic molecular beam injection in the HL-2A tokamak

Nuclear Materials and Energy, 2017
Reduction in the power load deposited onto the divertor target plates is achieved with supersonic molecular beam injection (SMBI) fuelling. The largest reduction in the heat flux profiles occurs at the outboard divertor separatrix strike point, while the
Jinming Gao, Jun Cheng, Chengyuan Chen, Longwen Yan, Wei Li, Jie Lu, Xiaoquan Ji, Yunbo Dong, Beibin Feng, Yi Liu, Qingwei Yang   +10 more
doaj   +1 more source

Comparison of arterial wall integration of different flow diverters in rabbits: The CICAFLOW study

, 2023
Géraud Forestier, Jonathan Cortese, Sylvia M. Bardet, Maxime Baudouin, Kévin Janot, V. Ratsimbazafy, Marie-Laure Perrin, Jérémy Mounier, Claude Couquet, Catherine Yardin, Yan Larragneguy, Flavie Souhaut, Romain Chauvet, Alexis Belgacem, Sonia Brischoux, Julien Magné, Charbel Mounayer, Faraj Terro, Aymeric Rouchaud   +18 more
openalex   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Collector probe analysis of tungsten transport to the far-SOL from the DIII-D SAS-VW divertor experiment

, 2023
S.H. Messer, Jeremy D. Mateja, J.H. Nichols, A. Cacheris, Jonah Duran, Shawn Zamperini, G. Sinclair, David Donovan, T. Abrams, T. Odstrčil, Jun Ren, Wendy Garcia, E.A. Unterberg, P.C. Stangeby, D.L. Rudakov, J.D. Elder, J.G. Watkins   +16 more
openalex   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source