Results 71 to 80 of about 1,646 (256)

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Dependence of turbulent transport on the divertor flux expansion in ASDEX Upgrade

Nuclear Fusion
Divertor concepts which are capable to handle the power exhaust of tokamaks remain a critical component on the path towards a magnetic confinement fusion reactor.
J. Pfennig-Bär, W. Zholobenko, A. Stegmeir, K. Eder, K. Zhang, T. Body, F. Jenko, the ASDEX Upgrade Team   +7 more
doaj   +1 more source

Survey of tungsten gross erosion from main plasma facing components in WEST during a L-mode high fluence campaign

Nuclear Materials and Energy
An initial high fluence campaign was performed in WEST, in 2023, on the newly installed actively cooled tungsten divertor composed of ITER-grade monoblocks.
N. Fedorczak, C. Arnas, L. Cappelli, L. Colas, Y. Corre, M. Diez, A. Gallo, J. Gaspar, A. Grosjean, C. Guillemaut, J.P. Gunn, C. Johnson, C. Martin, E. Tsitrone, E.A. Unterberg, J. Bucalossi   +15 more
doaj   +1 more source

Tungsten as a Structural Divertor Material

Advances in Science and Technology, 2010
Refractory materials, in particular tungsten base materials are considered as primary candidates for structural high heat load applications in future nuclear fusion power plants. Promising helium-cooled divertor design outlines make use of their high heat conductivity and strength. The upper operating temperature limit is mainly defined by the onset of
Rieth, M., Armstrong, D., Dafferner, B., Heger, S., Hoffmann, A., Hoffmann, M. D., Jäntsch, U., Kübel, C., Materna-Morris, E., Reiser, J., Rohde, M., Scherer, T., Widak, V., Zimmermann, H.   +13 more
openaire   +4 more sources

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Effects of N/Ne impurity seeding on the divertor asymmetry in HL-2A tokamak

Nuclear Fusion
Divertor asymmetry is a major challenge in achieving high-power, long-pulse discharges in future fusion reactors. Impurity seeding is the most common method for achieving divertor detachment in fusion devices.
Qingyi Tan, Haoran Ye, Xueyu Gong, Yijun Zhong, Qianhong Huang, Zhe Wang, Chengzhi Cao, Zhanhui Wang, Cailong Fu, Min Xu, Tao Yang   +10 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source