Results 91 to 100 of about 16,994 (249)

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Survey of tungsten gross erosion from main plasma facing components in WEST during a L-mode high fluence campaign

Nuclear Materials and Energy
An initial high fluence campaign was performed in WEST, in 2023, on the newly installed actively cooled tungsten divertor composed of ITER-grade monoblocks.
N. Fedorczak, C. Arnas, L. Cappelli, L. Colas, Y. Corre, M. Diez, A. Gallo, J. Gaspar, A. Grosjean, C. Guillemaut, J.P. Gunn, C. Johnson, C. Martin, E. Tsitrone, E.A. Unterberg, J. Bucalossi   +15 more
doaj   +1 more source

Thermographic studies of outer target heat fluxes on KSTAR

Nuclear Materials and Energy, 2017
A new infra-red (IR) thermography system with high spatial resolution has been installed on KSTAR and is now mainly applied to measure the outer divertor heat load profile.
H.H. Lee, R.A. Pitts, C.S. Kang, S.T. Oh, J.G. Bak, S.H. Hong, H.M. Wi, Y.S. Kim, H.S. Kim, D.C. Seo, H.T. Kim, K.M. Kim   +11 more
doaj   +1 more source

TPX divertor modeling studies [PDF]

, 1995
The Tokamak Physics Experiment (TPX) is designed to demonstrate features of an economically attractive steady state tokamak reactor. In this paper we present recent results from numerical studies of the proposed TPX divertor design (1), focusing on ...
Braams, B. J., Rensink, M. E., Brooks, J. N.   +2 more
core  

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Effects of N/Ne impurity seeding on the divertor asymmetry in HL-2A tokamak

Nuclear Fusion
Divertor asymmetry is a major challenge in achieving high-power, long-pulse discharges in future fusion reactors. Impurity seeding is the most common method for achieving divertor detachment in fusion devices.
Qingyi Tan, Haoran Ye, Xueyu Gong, Yijun Zhong, Qianhong Huang, Zhe Wang, Chengzhi Cao, Zhanhui Wang, Cailong Fu, Min Xu, Tao Yang   +10 more
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

ARIES-III divertor engineering design [PDF]

, 1992
This paper reports the engineering design of the ARIES-III double- null divertor. The divertor coolant tubes are made from W-3Re alloy and cooled by subcooled flow boiling of organic coolant.
Sze, D. K., Schultz, K. R., Herring, J. S., Wong, C. P. C., Ehst, D. A., Grotz, S., Brooks, J. N., Valenti, M., Cheng, E. T., Sharafat, S., Hasan, M. A., Najmabadi, F., Steiner, D.   +12 more
core   +2 more sources

Mechanical and electrical integration of the DTT divertor in the vacuum vessel [PDF]

openLa tesi consiste nell'utilizzo di un videoterminale messo a disposizione dal consorzio RFX al fine di condurre simulazioni con server di calcolo e di modellazione sul divertore.
BOVO, SAMUELE
core  

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source