Mapping the evolution of mitochondrial complex I through structural variation
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Local Convergence Analysis of an Eighth Order Scheme Using Hypothesis Only on the First Derivative
In this paper, we propose a local convergence analysis of an eighth order three-step method to approximate a locally unique solution of a nonlinear equation in a Banach space setting. Further, we also study the dynamic behaviour of that scheme.
Ioannis K. Argyros +2 more
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
How to Disagree: Negotiate Difference in a Divided World, by Adam Ferner and Darren Chetty
In writing 'How to Disagree', Ferner and Chetty aim to bring to light those assumptions we make about the world, its structure and the lived reality of what we assume to be real, in order to see how these assumptions affect the ways we engage with each ...
Elizabeth O'Brien
doaj +1 more source
Effects of intrathecal opioids use in cesarean section on breastfeeding and newborns’ weight gaining [PDF]
Objective: To assess the association between intrapartum intrathecal opioid use and breastfeeding and weight gain following cesarean section. Materials and methods: The prospective double-blinded study was conducted on term pregnant women, undergoing ...
Anbarafshan, Mohammad +6 more
core +1 more source
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
The effect of spatial learning on the number of astrocytes in rat dentate gyrus [PDF]
In this study, we evaluated the effect of spatial learning on the number of astrocytes in the rat dentate gyrus with Morris water maze. Fifteen male albino Wistar rats were divided into three groups as control, reference memory and working memory groups.
Hosseini, A. +3 more
core
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Use of identity of A. Hurwitz for construction of a linear positive operator of approximation
By using a general algebraic identity of Adolf Hurwitz [1], which generalizes an important identity of Abel, we construct a new operator \(S_m^{(\beta_1,\ldots,\beta_m)}\) approximating the functions. A special case of this is the operator \(Q_m^\beta\)
Dimitrie D. Stancu
doaj +2 more sources
Blood pressure response to Cold Pressor Test in the children of hypertensives [PDF]
Two hundred student volunteers of 16-24 yrs were divided into two groups of 100 each, as children of hypertensive and children of normotensive parents. It was observed that there was no difference in resting SBP and DBP in both groups before CPT.
Garg, S, Kumar, A, Singh, KD
core +1 more source

