Results 111 to 120 of about 348,820 (310)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LOVE IN THE “UNIDIVERSE”: A SALESIAN PERSPECTIVE ON CHANCE
Zygon, 2009 The notion of the universe evolving through an interplay of law and chance raises numerous theological questions. In particular, scientific evidence of chance confronts images of God and divine action within this emerging worldview.
doaj +2 more sources
Solving the Socratic Problem—A Contribution from Medicine [PDF]
, 2018 This essay provides a medical theory that could clarify enigmas surrounding the historical Socrates. It offers textual evidence that Socrates had temporal lobe epilepsy and that its two types of seizure manifested as recurrent voices and peculiar ...
Muramoto, Osamu
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Triadic to Trinitarian: Kevin J. Vanhoozer’s Application of J.L. Austin’s Speech Act Theory [PDF]
, 2010 The basis for Christian theology, the Bible, has come under considerable attack by decontructionalists in their attempt to disregard authorial intent and to prove that understanding the meaning of an author\u27s words is an impossible task.
Stone, Joshua C
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Callimachus and Arcadian metamorphoses: Hy. 1, 29-32 and Hy. 1, 37-41
AitiaOne of the most relevant characteristics of Callimachus’ hymnic poetry is, among other aspects, its manifest heterogeneity of forms and themes in each of the six poems that compose the collection.
Sandra M.ª Plaza Salguero
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Divine Action in the World of Physics: Response to Nicholas Saunders
Zygon, 2000 Nicholas Saunders claims that, in my view, divine action requires and is confined to indeterminacies at the quantum level. I try to make clear that, in speaking of “gaps” in physical causality, I mean that the existence of intentions entails that ...
doaj +2 more sources