Results 111 to 120 of about 12,934 (295)

Callimachus and Arcadian metamorphoses: Hy. 1, 29-32 and Hy. 1, 37-41

open access: yesAitia
One of the most relevant characteristics of Callimachus’ hymnic poetry is, among other aspects, its manifest heterogeneity of forms and themes in each of the six poems that compose the collection.
Sandra M.ª Plaza Salguero
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Divine Action in the World of Physics: Response to Nicholas Saunders

open access: yesZygon, 2000
Nicholas Saunders claims that, in my view, divine action requires and is confined to indeterminacies at the quantum level. I try to make clear that, in speaking of “gaps” in physical causality, I mean that the existence of intentions entails that ...
doaj   +2 more sources

Divine Action and Teleology in an Evolutionary World

open access: yes, 2017
In this paper I explore three possibilities: 1) whether or not there is room for divine action in a dynamic, undetermined, evolutionary world; 2) if divine action is necessary to explain the outcome of creation; and 3) if there is purpose (e.g. teleology)
Sparks, Emily
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Providence as “Responsible Risk-Taking”

open access: yesTheoLogica
This paper explores the concept of divine providence in the framework of open theism, focusing on the balance between God’s sovereignty and creaturely libertarian free will.
Johannes Grössl
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

With God in mind: divine action and the naturalisation of consciousness [PDF]

open access: yes, 2017
This thesis addresses the question of divine action in the mind: Is human consciousness a uniquely nonphysical causal joint wherein divine intentions meet natural realities without contravening lawlike physical processes?
Ritchie, Sarah Lane
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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