Results 121 to 130 of about 3,124,156 (300)
SCIENCE AND SERIOUS THEOLOGY: TWO PATHS FOR SCIENCE AND RELIGION'S FUTURE?
Zygon, 2010 Although they take different approaches, both Taede A. Smedes and Kevin Sharpe have challenged the theology‐and‐science enterprise and raised important questions about theological and scientific assumptions behind this work.
doaj +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Participatory action research and living theory action research in the Northern Territory
, 2013 This article is based on my honours thesis, ‘You or Me? A Social Framework in support of Indigenous community organisation’. It gives an overview of the reflective learning processes analysed in the thesis as I positioned myself as a community ...
Beattie, Michael
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
EMPOWERMENT IN PARTICIPATORY ACTION RESEARCH CONDUCTED IN MALAYSIA
, 2014 Participatory action research advocates participation and egalitarian relationship among its participants. This study was conducted in Malaysia amongst the Malay society, where the Malay society has been labelled as having high power distance in its ...
Puteh-Behak, Fariza
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Improving Indigenous Women’s Wellness Through Action Research
, 2013 This paper describes an action research project undertaken with Indigenous women in the highly urbanised area of north Brisbane. The project was a collaborative effort to move beyond the alarming statistics of Indigenous women’s poor health status.
Walker, Melissa +2 more
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