Results 31 to 40 of about 118,766 (310)
Normative Reasons, Epistemic Autonomy, and Accountability to God
Religions, 2023 According to many, human autonomy is necessary for moral action and yet incompatible with being morally accountable to God’s divine commands. By issuing commands that ground normative facts, God demands our accountability without understanding our ...
Brandon Rickabaugh
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Virtue Depends on Natural Law and Divine Commands
ReligionsVirtue theory has occupied a place of relative prominence within the Christian intellectual tradition. But there is a problem facing it: how one contemplates the virtues and vices will ultimately depend upon deeper accounts of the good and the right ...
J. Caleb Clanton, Kraig Martin
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Inexpressibility in Augustine’s Just War Theory: Lessons for Modern Warfare [PDF]
, 2012 St. Augustine\u27s Just War Theory is relatively unique in the history of just war in that he relies heavily on Divine involvement in his doctrine of just war.
Beard, Matt
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
"... in God only one infinite act can be thought...": The Ambiguity of Divine Agency and the Diversity of Evil [PDF]
, 2015 The paper argues that God does not act but is creative activity, which helps to overcome evil by the possibilities of the good that it opens up for creatures in the face of ...
Dalferth, Ingolf U.
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Can Ethics Exist Without God? A Thomistic Critique of James Sterba’s Axiomatic Morality
ReligionsThis essay explores the question: can we have an objective ethics without God? This question is raised by James Sterba, who argues in the affirmative. As an atheistic ethicist, Sterba is motivated to maintain an objective morality that is not based in ...
Joseph Brian Huffling
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source