Results 41 to 50 of about 5,888,690 (275)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

The Psychopath Challenge to Divine Command Theory: Reply to Flannagan

, 2023
Erik Wielenberg has presented an objection to divine command theory (DCT) alleging that DCT has the troubling implication that psychopaths have no moral obligations. Matthew Flannagan has replied to Wielenberg’s argument.
Wielenberg, Erik J., Erik J. Wielenberg
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Sterba’s Argument from Evil and Objections to Divine Command Theory

Religions
This paper will respond to James Sterba’s paper “An Ethics without God That is Compatible with Darwinian Evolution”. In his paper, Sterba argues that God cannot be the source of morality.
Caleb Cumberland
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Sterba on Divine Commands and Fairness

Religions
James Sterba has recently argued against Divine Command Theory (DCT). Sterba also offers, as a preferable alternative to DCT, a metaethical account which he has developed over a number of years (culminating in Sterba’s 2013 book), which attempts to ...
Daniel Molto
doaj   +1 more source

The Existence of God and the Efficacy of Morality [PDF]

پژوهشنامه فلسفه دین, 2015
In this paper, after a brief description of some common moral arguments for the existence of God, there is suggested a new argument entitled "necessity of the existence of a compensatory world or God for efficacy of morality". It is believed that in some
Masoud Sadeghi, Asadollah Azhir
doaj   +1 more source

Does Darwall’s Morality of Accountability Require Moral Realism? (And Would It Be Strengthened by Adding God to the Story?)

Religions, 2021
Stephen Darwall has developed an account of moral obligations as grounded in “second-personal reasons,” which was developed in conversation with early modern “theological voluntarists” who were divine command theorists.
C. Stephen Evans
doaj   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source