Results 31 to 40 of about 1,397 (281)

A Study and Explanation of the Theory of General Justice in the View of St. Thomas Aquinas [PDF]

Pizhūhish/hā-yi Falsafī- Kalāmī, 2020
General Justice is a virtue that leads people to the community order and goods through which they can achieve well-being. This article explains the theory of general justice from the perspective of Aquinas and examines the common good and its role as the
Abdollah Abedifar, Mohsen Javadi
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mediated Morality as a Middle Position in Understanding the Relation between God and Morality

Religions, 2023
How should we understand the relation between God and morality? This article aims to address this question by constructing a theistic metaethical theory informed by postphenomenological mediation theory. According to postphenomenological mediation theory,
Amund Tobias Måge Areklett, Atle Ottesen Søvik   +1 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Normative Reasons, Epistemic Autonomy, and Accountability to God

Religions, 2023
According to many, human autonomy is necessary for moral action and yet incompatible with being morally accountable to God’s divine commands. By issuing commands that ground normative facts, God demands our accountability without understanding our ...
Brandon Rickabaugh
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Divine Command Theory and morality within Shari'a

, 2023
Divine Command Theory är en metaetisk position som innebär att vår moraliska kompass bör grunda sig i vad Gud anser är rätt eller fel. Givet att det existerar objektiva moraliska sanningar, är Divine Command Theory den mest lämpliga teorin för att på ett
Yahya, Ahmed Zeki
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Can Ethics Exist Without God? A Thomistic Critique of James Sterba’s Axiomatic Morality

Religions
This essay explores the question: can we have an objective ethics without God? This question is raised by James Sterba, who argues in the affirmative. As an atheistic ethicist, Sterba is motivated to maintain an objective morality that is not based in ...
Joseph Brian Huffling
doaj   +1 more source