Results 51 to 60 of about 147,317 (313)

Can Ethics Exist Without God? A Thomistic Critique of James Sterba’s Axiomatic Morality

open access: yesReligions
This essay explores the question: can we have an objective ethics without God? This question is raised by James Sterba, who argues in the affirmative. As an atheistic ethicist, Sterba is motivated to maintain an objective morality that is not based in ...
Joseph Brian Huffling
doaj   +1 more source

What is a Merciful Heart? Affective-Motivational Aspects of the Second Love Command [PDF]

open access: yes, 2017
In this paper, I argue that Christ’s second love command implies not only that people’s volitions and actions be Christ-like, but also that their affective-motivational dispositions be Christ-like. More specifically, I argue that the command implies that
Vitz, Rico
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Mishpat Ivri, Halakhah and Legal Philosophy: Agunah and the Theory of “Legal Sources" [PDF]

open access: yes, 2001
In this paper, I ask whether mishpat ivri (Jewish Law) is appropriately conceived as a “legal system”. I review Menachem Elon’s use of a “Sources” Theory of Law (based on Salmond) in his account of Mishpat Ivri; the status of religious law from the ...
Jackson, Bernard S.
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

The Existence of God and the Efficacy of Morality [PDF]

open access: yesپژوهشنامه فلسفه دین, 2015
In this paper, after a brief description of some common moral arguments for the existence of God, there is suggested a new argument entitled "necessity of the existence of a compensatory world or God for efficacy of morality". It is believed that in some
Masoud Sadeghi, Asadollah Azhir
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Sterba on Divine Commands and Fairness

open access: yesReligions
James Sterba has recently argued against Divine Command Theory (DCT). Sterba also offers, as a preferable alternative to DCT, a metaethical account which he has developed over a number of years (culminating in Sterba’s 2013 book), which attempts to ...
Daniel Molto
doaj   +1 more source

Interpreting Hobbes’s Moral Theory: Rightness, Goodness, Virtue, and Responsibility

open access: yesتأملات اخلاقی, 2021
The paper argues that the moral philosophy of Thomas Hobbes is unified by a complex conception of reason that imposes consistency norms of both rationality and reasonableness.
S. A. LLOYD
doaj  

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