Results 51 to 60 of about 360,504 (311)
, 2012 Leon Battista Alberti and Marsilio Ficino, though separated by twenty-nine years in age, had a close relationship as mentor and pupil. Concepts which can be found in Alberti’s De pictura (1435) and De re aedificatoria (1450) are infused in Ficino’s De ...
Hendrix, John S
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Christian Insights into Plotinus' Metaphysics and his Concept of Aptitude (Ἐπιτηδειότης) [PDF]
, 2017 Modern scholarship on Late Antique philosophy seems to be more interested than ever before in examining in depth convergences and divergences between Platonism and Early Christian thought. Plotinus is a key gure in such an examination.
Pavlos, Panagiotis
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
La musique sacralisée dans les œuvres de quelques écrivains romantiques
Quêtes Littéraires, 2013 This article analyses poetic visions, based on synesthesia and referring to Swedenborg’s correspondence theory, evoked by listening to music. In these visions the musical impressions are in some way sanctified and they contribute to the development of ...
Anna Opiela
doaj +1 more source
The Divine Christology of 'Remember Me' (Luke 23:42) in Light of Lament
Tyndale Bulletin, 2023 Luke’s crucifixion scene includes a brief and unique exchange between the crucified Jesus and an unidentified crucified individual often referred to as the ‘penitent thief’. The dialogue between the two only spans two verses (Luke 23:42-43).
Channing L. Crisler
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Writing Dirty: Paradoxical Embodiments of Nazism in Bataille\u27s Le Bleu du Ciel [PDF]
, 2004 Since his death in 1962, and particularly in the last twenty-five years, Georges Bataille has become a major figure in intellectual circles. Critics such as Roland Barthes, Jacques Derrida, Michel Foucault, Julia Kristeva and Philippe Sollers, to name ...
Vanbaelen, Sylvie
core +2 more sources