The fitness costs of reproductive specialization scale inversely with organismal size. [PDF]
Zhang C +4 more
europepmc +1 more source
SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao +11 more
wiley +1 more source
The Impact of Parental Mathematical Education Anxiety and Positive Suggestion Intervention on Children's Mathematics Achievement. [PDF]
Zhou D +6 more
europepmc +1 more source
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Hybrid deep learning and feature selection approach for autism detection from rs-fMRI data. [PDF]
Abd Elaziz M +8 more
europepmc +1 more source
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
Contralaterally controlled functional electrical stimulation for upper limb motor impairment in people after stroke. [PDF]
Aoki K +5 more
europepmc +1 more source
Hierarchical Artificial Muscle with Nonlinear Elasticity for Antagonistic and Cyclic Robotics
We construct hierarchical muscles by plying nylon fibers around a heating wire. The hierarchical muscle shows a J‐shaped passive curve, which shows benefit in antagonistic muscle pair and work accumulation mechanism. We also develop a computational, first‐principle model to understand the physics of both active actuation stroke and passive J‐curve ...
Samuel Tsai +15 more
wiley +1 more source
Use of a specific set of learner-centered evidence-based teaching practices correlates with higher exam performance across seven STEM departments. [PDF]
Jackson MA +4 more
europepmc +1 more source

