Results 201 to 210 of about 550,146 (278)

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation

Advanced Science, EarlyView.
This study demonstrates that Piezo1 activation enhances FAK‐YAP‐mediated upregulation of PD‐L1 and CXCL10, thereby promoting an immunotherapy‐responsive tumor microenvironment in NSCLC. Cyclic stretch modulates the PD‐L1/CXCL10 response to ECM stiffness, reshaping their expression dynamics.
Tian Zhang, Yuan Li, Bo Cheng, Zhao Xu, Mengjie Liu, Jinteng Feng, Yixue Bai, Yang Yu, Panpan Jiang, Luying Geng, Feng Xu, Hui Guo   +11 more
wiley   +1 more source

Gompertz Law‐Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks

Advanced Science, EarlyView.
The Gompertz law‐based biological age metric (GOLD BioAge) introduces interpretable convenient and interpretable calculations to capture mortality, disease, and frailty risks. Its applications to proteomics and metabolomics (ProtAge and MetAge) demonstrate clinical potential to enhance aging evaluation and prevent age‐related diseases.
Meng Hao, Hui Zhang, Jingyi Wu, Yaqi Huang, Xiangnan Li, Meijia Wang, Shuming Wang, Jiaofeng Wang, Jie Chen, Zhi jun Bao, Li Jin, Xiaofeng Wang, Zixin Hu, Shuai Jiang, Yi Li   +14 more
wiley   +1 more source

Quantitative Electron Beam‐Single Atom Interactions Enabled by Sub‐20‐pm Precision Targeting

Advanced Science, EarlyView.
Atomic lock‐on (ALO) is a rapid, low‐dose in situ technique in scanning transmission electron microscopy (STEM) that achieves sub‐20 picometer (pm) beam positioning. A sparse annular scan collects positional information while avoiding irradiation of the target site.
Kevin M. Roccapriore, Frances M. Ross, Julian Klein   +2 more
wiley   +1 more source

PRO‐LDM: A Conditional Latent Diffusion Model for Protein Sequence Design and Functional Optimization

Advanced Science, EarlyView.
PRO‐LDM is a modular latent diffusion framework that learns hierarchical biological representations to enable efficient and high‐fidelity protein design. PRO‐LDM can design species that resemble natural sequences with enhanced diversity or optimize protein functions.
Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing   +15 more
wiley   +1 more source

Symmetry Breaking in Meniscus Splitting: Effects of Boundary Conditions and Polymeric Membrane Growth

Advanced Science, EarlyView.
Meniscus splitting in the drying of a viscous polymer dispersion is investigated by focusing on nucleation of multiple nuclei with symmetry breaking and asynchronous nucleus formation. Controlled by spatial boundaries, the first nucleus is generated at a position shifted away from the space center and strongly facilitates the asynchronous second ...
Thi Kim Loc Nguyen, Taisuke Hatta, Koji Ogura, Yoshiya Tonomura, Kosuke Okeyoshi   +4 more
wiley   +1 more source

Dedifferentiation and Transfer in Executive Function and Math Ability Following a Five‐Year Abacus Training in Schoolchildren

Advanced Science, EarlyView.
While cognitive development typically exhibits differentiation, marked by decreasing inter‐domain correlations, this study demonstrates that five‐year abacus training is associated with de‐differentiation of executive function and mathematical ability in school‐aged children.
Tianyong Xu, Xinyang Liu, Hongjian He, Changsong Zhou, Andrea Hildebrandt, Feiyan Chen   +5 more
wiley   +1 more source

Choices of Pre-service Elementary Mathematics Teachers’ Instructional Explanations: Division by Zero

, 2017
Fatih Karakuş
openalex   +2 more sources

Modeling the effects of treatment adherence challenges on the transmission dynamics of hepatitis C virus. [PDF]

PLoS One
Mupedza TV, Mhlanga L, Mamutse D, Helikumi M, Lolika PO, Murambiwa ST, Mhlanga A.   +6 more
europepmc   +1 more source

EFFECTIVENESS MODEL OF LEARNING CYCLE “5E”AND STUDENT TEAM ACHIEVEMENT DIVISION (STAD) ON MATHEMATICS LEARNING OUTCOMES IN GRADE VIII OF EVEN SEMESTER IN SMP NEGERI 1 SEDAYU

, 2017
Melina Asmanti Rahmi, Aris Thobirin
openalex   +1 more source

ChromInSight: Revealing DNA Double‐Strand Breaks Through Chromatin Structural Insights With an Interpretable Graph Neural Network Framework

Advanced Science, EarlyView.
DSBs are the most critical genomic lesions. Using the ChromInSight framework, It is revealed that 3D chromatin structure, rather than linear distance, shapes cluster‐scene between hub‐Nodes and DSB loci. The “spatial isolation–damage containment” hypothesis is proposed to illustrate how the genome responds to genomic damage and offer a powerful tool ...
Kang Xu, Zongyuan Yu, Canzhuang Sun, Conglin Gou, Jiangyue Zhu, Jun Wang, Xiaochen Bo, Guoxian Yu, Hao Li, Hebing Chen   +9 more
wiley   +1 more source