Results 231 to 240 of about 550,146 (278)

SGCD: High‐Resolution Spatial Domain Characterization via Data Interpolation and Cell‐Type Deconvolution

open access: yesAdvanced Science, EarlyView.
SGCD presents a novel approach for tissue spatial domain identification by employing interpolation to estimate inter‐spot gene expression and deconvolution to resolve cell‐type composition in both sampled and interstitial regions. By integrating gene expression, cell type, and spatial coordinates within a graph contrastive learning framework, SGCD ...
Tianjiao Zhang   +7 more
wiley   +1 more source

MGPT: A Multi‐task Graph Prompt Learning Framework for Drug Discovery

open access: yesAdvanced Science, EarlyView.
MGPT is a unified multi‐task graph prompt learning model providing generalizable and robust graph representations for few‐shot drug association prediction. MGPT demonstrates the ability of seamless task switching and outperforms competitive approaches in few‐shot scenarios.
Yang Li   +4 more
wiley   +1 more source

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

open access: yesAdvanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun   +14 more
wiley   +1 more source

Telemedicine Use among Adults with Kidney Disease in the United States. [PDF]

open access: yesKidney360
Shah RM   +7 more
europepmc   +1 more source

Optimal bandwidth selection in stochastic regression of Bio-FET measurements. [PDF]

open access: yesJ Math Biol
Melara LA   +4 more
europepmc   +1 more source

Author Correction: Nutrient loading as a key cause of short- and long-term anthropogenic ecological degradation of the Salton Sea. [PDF]

open access: yesSci Rep
Hung C   +8 more
europepmc   +1 more source

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