Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao+7 more
wiley +1 more source
Author Correction: Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes. [PDF]
Huerta-Chagoya A+25 more
europepmc +1 more source
Elastic Fiber Programming for Simplified Pneumatic Control in Soft Robots
This study introduces a novel approach to designing pneumatic soft actuators by leveraging elastic fiber programming to achieve tailored constitutive equations. Using pre‐stretched elastic fibers with varying properties and modurization, the soft robots can demonstrate diverse motions from a single pressure source. This simplifies control systems while
Xiaoli Yang+7 more
wiley +1 more source
Correction: Nanocellulose/wood ash-reinforced starch-chitosan hydrogel composites for soil conditioning and their impact on pea plant growth. [PDF]
Iqbal DN+7 more
europepmc +1 more source
Contrast Agent Clearance Dynamics and Diffusion in the Mouse Brain After Ventricular Administration
Schematic representation of contrast agent clearance by convective bulk flow from the ventricular spaces to the subarachnoid space on the ventral aspect of the brain, or by diffusion into the parenchyma across the pia‐glia or through the semi‐permeable ependyma. Abstract Fluid and solute exchange between cerebrospinal fluid (CSF) spaces and the central
Yann Decker+2 more
wiley +1 more source
Air Pollution Increases Healthcare Utilization Below Safe Thresholds in Individuals With Asthma. [PDF]
Lee H+6 more
europepmc +1 more source
The rare‐earth intermetallics YAuGe is identified as a Kramers nodal‐line semimetal, a topological state inherent to non‐centrosymmetric achiral lattices. Magnetic rare‐earth substitution induces an anomalous Hall effect, highlighting the impact of time‐reversal symmetry breaking on topological electronic states and offering insights into designing the
Takashi Kurumaji+13 more
wiley +1 more source
Mathematical study of silicate and oxide networks through Revan topological descriptors for exploring molecular complexity and connectivity. [PDF]
Zhang Q+5 more
europepmc +1 more source