Results 71 to 80 of about 44,181 (267)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Drawing a scientific map of the divorce research field using co-citation analysis [PDF]
مجله علمسنجی کاسپین, 2020 Background and aim: One of the applications of scientometrics is the drawing of scientific maps carried out with various techniques including co-citation.
Rouhallah Khademi +1 more
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A qualitative study of the process of children's adaptation to divorce of parents [PDF]
Faṣlnāmah-i Farhang Mushavirah va Ravān/DarmānīAdapting to the divorce of parents is one of the challenges that the children of divorce face, the absence of which can cause adverse consequences for the children of divorce and the society.
Zohre Salehbeigi +2 more
doaj +1 more source
Psychiatria Danubina, 2020 Divorce is a life event with a high level of stress for the entire family. Research shows that the number of divorces is on a steady rise. Family is very important for development of the children and changes within the family, after the divorce, could make consequences on them.
openaire +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
DIVORCE IN SOUTH AFRICA: AN OVERVIEW
Social Work/Maatskaplike Werk, 2004 This article provides an overview of South African divorce figures given for the past five years. The various ways in which divorce figures can be expressed are considered, with specific reference to South Africa.
L Ackermann
doaj +1 more source