Results 71 to 80 of about 98,283 (310)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The Effect of Joint Custody on Marriage and Divorce [PDF]

Since the 1970s almost all states have introduced a form of joint custody after divorce. We analyze the causal effect of these custody law reforms on the incidence of marriage and divorce.
Martin Halla
core   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Economics of marriage and divorce [PDF]

In order to understand these ideas, we have to develop a model of both marriage and divorce (or, in other words, a model that allows for changes over time in the utility from marriage).
Leora Friedberg, Steven Stern
core  

Relationship between Divorce and Well-being among Older Europeans

Psichologija
This study explores the relationship between divorce and well-being among older Europeans (50+), utilizing data from eight waves of the Survey on Health, Ageing and Retirement in Europe (SHARE).
Giedrius Rupšys, Olga Zamalijeva, Antanas Kairys   +2 more
doaj   +3 more sources

Divorce Motives in a Period of Rising Divorce

Journal of Family Issues, 2006
Using survey data on 1,718 ever-divorced men and women in the Netherlands, the authors describe the motives people give for their divorce. The authors distinguish motives regarding three types of issues: relational issues, behavioral problems, and problems about work and the division of labor.
Graaf, Paul M. de, Kalmijn, Matthijs
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A qualitative study of the process of children's adaptation to divorce of parents [PDF]

Faṣlnāmah-i Farhang Mushavirah va Ravān/Darmānī
Adapting to the divorce of parents is one of the challenges that the children of divorce face, the absence of which can cause adverse consequences for the children of divorce and the society.
Zohre Salehbeigi, Abolfazl Hatami Varzaneh, kiimars farahbakhsh   +2 more
doaj   +1 more source

Divorce Adjustment:Reflection on Divorced Womens’s Lived Experience of Divorce Adjustment

فصلنامه زن و جامعه, 2023
Introduction: This study aimed to investigate the lived experiences of divorced women in adjusting to divorce. Methods: The qualitative research method of phenomenology was used in this study. The statistical population included divorced women in Shiraz in 2019-2020. Purposive sampling was used to select the participants.
Soheila Bastani, Maryam Golamzadeh jofreh, Mansour Sodani   +2 more
openaire   +1 more source