Results 81 to 90 of about 137,353 (312)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Divorce and the birth control pill [PDF]
This paper explores the role of the birth control pill on divorce. To identify its effect, we use a quasi experiment exploiting the differences in the language of the Comstock anti-obscenity statutes approved in the 1800s and early 1900s in the US ...
MARCÉN, MIRIAM
core
Drawing a scientific map of the divorce research field using co-citation analysis [PDF]
مجله علمسنجی کاسپین, 2020 Background and aim: One of the applications of scientometrics is the drawing of scientific maps carried out with various techniques including co-citation.
Rouhallah Khademi +1 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Exploring the causes of divorce among applicants and experts in the field of divorce in the city of Rasht: emphasizing the commission of crimes arising from marital maladjustment [PDF]
مجله علوم روانشناختیBackground: Divorce is a social issue that has witnessed an upward trend in recent years, exerting negative effects on families, children, and society. One significant factor contributing to divorce is marital misconduct, which may lead to the commission
Hojjat Falah Khajakini +3 more
doaj
Divorce Motives in a Period of Rising Divorce
Journal of Family Issues, 2006 Using survey data on 1,718 ever-divorced men and women in the Netherlands, the authors describe the motives people give for their divorce. The authors distinguish motives regarding three types of issues: relational issues, behavioral problems, and problems about work and the division of labor.
Graaf, Paul M. de, Kalmijn, Matthijs
openaire +3 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Does cancer affect the divorce rate? [PDF]
Discrete-time hazard regression models were employed to register and census data on 1.4 million Norwegian married couples from 1974-2001 to explore the probability of divorce following cancer illness.
Astri Syse, Øystein Kravdal
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Divorce Adjustment:Reflection on Divorced Womens’s Lived Experience of Divorce Adjustment
فصلنامه زن و جامعه, 2023 Introduction: This study aimed to investigate the lived experiences of divorced women in adjusting to divorce. Methods: The qualitative research method of phenomenology was used in this study. The statistical population included divorced women in Shiraz in 2019-2020. Purposive sampling was used to select the participants.
Soheila Bastani +2 more
openaire +1 more source