Results 91 to 100 of about 195,313 (255)

Graphic representation of the burden of suffering in dizziness patients [PDF]

, 2014
Background: Dizziness adversely affects an individual?s well-being. However, its impact is not only influenced by its physical manifestations, but also by its subjective importance to the patient.
Weidt, Steffi; https://orcid.org/, Steffi Weidt, Büchi, Stefan, Hegemann, Stefan, Moergeli, Hanspeter, Bruehl, Annette Beatrix, Hanspeter Moergeli, Straumann, Dominik, Stefan Hegemann, Michael Rufer, Stefan Büchi, Dominik Straumann, Annette Beatrix Bruehl, Rufer, Michael, Straumann D, Hegemann S, Rufer M, Weidt S, Bruehl AB, Moergeli H, Büchi S   +20 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source

Anti-saccade as a tool to evaluate cognitive impairment in vestibular migraine

Frontiers in Neurology
BackgroundVestibular migraine (VM), an intricate subtype of migraine, amalgamates the dual attributes of migraine and vestibular disorders. In clinical settings, individuals with VM frequently articulate concerns regarding the manifestation of subjective
Lingmei Lu, Wenyu Ni, Yin Liu, Li Sun, Fei Li   +4 more
doaj   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Psychological Variables Mediate Symptoms in Persistent Postural‐Perceptual Dizziness (PPPD): A Cross‐Sectional Self‐Report Study

BACKGROUND: Persistent Postural‐Perceptual Dizziness (PPPD) is a prevalent functional neuro‐otologic disorder characterised by non‐spinning vertigo, perceived instability and visual motion sensitivity.
Ellmers, Toby, Diego Kaski, Hazar, Ali‐Mert, John F. Golding, Golding, John, Kaski, Diego, Ju Cheng Lam, Ariel Sereda, Ali-Mert Hazar, Toby Ellmers, Sereda, Ariel, Lam, Ju Cheng   +11 more
core   +1 more source

Dizziness in the Elderly [PDF]

, 2015
Vertigo is a common complaint in the elderly since disease-related vestibular dysfunction may be superimposed on the normal aging process. Accordingly, the manifestation or response to treatments of vestibular disorders may differ in the elderly.
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Period Prevalence of Dizziness and Vertigo in Adolescents. [PDF]

, 2015
To assess the period prevalence and severity of dizziness and vertigo in adolescents.In 1661 students in 8th-10th grade in twelve grammar schools in Munich, Germany information on vertigo/dizziness was assessed by a questionnaire in the class room ...
Straube, Andreas, Filippopulos, Filipp, Kries, Rüdiger von, Florian Heinen, Langhagen, Thyra, Rüdiger von Kries, Andreas Straube, Klaus Jahn, Klaus Jahn (551544), Lucia Albers (794250), Rüdiger von Kries (328637), Jahn, Klaus, Landgraf, Mirjam N., Andreas Straube (284901), Albers, Lucia, Lucia Albers, Lucia Gerstl (794253), Heinen, Florian, Lucia Gerstl, Mirjam N Landgraf, Thyra Langhagen, Gerstl, Lucia, Filipp Filippopulos, Thyra Langhagen (794249), Filipp Filippopulos (794251), Florian Heinen (284902), Mirjam N. Landgraf (794252), Filippopulos Filipp, Albers Lucia, Gerstl Lucia, Jahn Klaus, von Kries Rüdiger, Straube Andreas, Heinen Florian, Langhagen Thyra, Landgraf Mirjam N.   +35 more
core   +2 more sources

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source