Results 61 to 70 of about 52,371 (280)

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Overall survival and progression-free survival between polyploid DLBCL, NOS (n = 51) and control DLBCL, NOS (n = 53) patients.

, 2018
(A) The overall survival curves were significantly worse for polyploid DLBCL than control DLBCL (p = 0.04). (B) The progression-free survival curves were not significantly different between the polyploid DLBCL and control DLBCL (p = 0.49).
Takuto Miyagishima (5088950), Hiroaki Miyoshi (2818363), Junichi Kiyasu (5088947), Masao Seto (73894), Tomohiko Kamimura (287232), Takanori Teshima (2816914), Joji Shimono (5088944), Koji Nagafuji (410643), Koichi Ohshima (230585), Tetsuya Eto (3571922)   +9 more
core   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression

VIEW, EarlyView.
Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang, Dongxue Ge, Wanqi Yang, Haobin Shen, Weihong Ge, Li Li, Dayu Chen, Jinglin Wang   +7 more
wiley   +1 more source

Caracterización biológica y pronóstica del linfoma difuso de células grandes en la era de la inmunoquimioterapia [PDF]

, 2011
El linfoma difuso de células grandes (LDCGB) es la neoplasia linfoide agresiva más frecuente en el mundo occidental. Sin embargo, es una entidad nosológica heterogénea de difícil caracterización por técnicas convencionales.
Gutiérrez García, Gonzalo
core   +3 more sources

Vitamin D receptor expression in germinal centre type diffuse large B-cell lymphoma cells is associated with vitamin D insensitivity

Endocrine Oncology
Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of non-Hodgkin lymphomas (NHLs) often sub-classified into major germinal centre (GC) and activated B-cell (ABC) cell-of-origin types.
Elizabeth J Soilleux, Amanda Anderson, Emma Roberts, Linden Lyne, Kah Keng Wong, Hayley Spearman, Stefano Casola, Alison H Banham, Duncan M Gascoyne   +8 more
doaj   +1 more source

Whispers from the Liver: A Hidden Case of CD10+ High-Grade B-cell Lymphoma [PDF]

Documenta Haematologica
Background: High-grade B-cell lymphomas involving the liver are rare and often present with vague, nonspecific symptoms. Clinically, these lymphomas can easily be mistaken for more common hepatic or infectious diseases, which, unfortunately, tends to ...
Nasim SALIMIAGHDAM, Ummi KHAN, Ruchit SHAH   +2 more
doaj   +1 more source

Anaplastic Lymphoma Kinase positive large B cell lymphoma of ileocaecal mesentery: A case report

Indian Journal of Pathology and Microbiology, 2020
ALK+ large B cell lymphoma (LBCL) is a very rare aggressive neoplasm. It accounts for less than 1% of diffuse large B cell lymphoma (DLBCL). This is a case report of ALK+ DLBCL in a 34-year-old woman with an ileocaecal mesenteric mass.
Aravinth Subramaniam, Divya Gnanasekaran, Saravanakumar Suruliraj, Palanivelu Chinnusamy   +3 more
doaj   +1 more source

Pathological Features of MYC IHC-High DLBCL.

, 2012
Pathological Features of MYC IHC-High DLBCL.
Margaret A. Shipp (171976), Geraldine S. Pinkus (171973), Michael J. Kluk (171954), Papiya Sinha (171956), Alyssa Roy (171958), Donna S. Neuberg (171966), Stefano Monti (171969), Scott J. Rodig (121834), Paola Dal Cin (171962), Bjoern Chapuy (171955)   +9 more
core   +1 more source

Review on enhancing clinical decision support system using machine learning

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract Clinical decision‐making is a complex patient‐centred process. For an informed clinical decision, the input data is very thorough ranging from detailed family history, environmental history, social history, health‐risk assessments, and prior relevant medical cases.
Anum Masood, Usman Naseem, Junaid Rashid, Jungeun Kim, Imran Razzak   +4 more
wiley   +1 more source