Results 131 to 140 of about 34,646 (215)

Results of a phase II open-label, multiple-dose study of vamorolone (VBP15-006) in 7- to < 18-year-old boys with duchenne muscular dystrophy. [PDF]

J Neurol
Lochmüller H, Gonorazky H, Nigro E, Mah JK, Alemán A, Yaworski A, Oskoui M, Sbrocchi AM, Selby K, de Vera A, McAdam L, Gresko E, Linden A, Dutreix C, Hoffman EP.   +14 more
europepmc   +1 more source

Neuromuscular and neuromechanical assessments of respiratory performance in the mdx mouse model of Duchenne muscular dystrophy across the natural history of disease

Experimental Physiology, EarlyView.
Abstract Duchenne muscular dystrophy (DMD) is a severe life‐limiting X‐linked neuromuscular disorder characterised by progressive skeletal muscle degeneration and respiratory failure. The mdx mouse, lacking dystrophin, is the most widely used preclinical model of DMD, yet the trajectory of respiratory dysfunction in this model remains incompletely ...
Michael N. Maxwell, Christopher G. Wilson, Mai K. Elmallah, Federica Trucco, Ken D. O'Halloran   +4 more
wiley   +1 more source

DWORF expression is reduced in a large animal model of Duchenne muscular dystrophy

Disease Models & Mechanisms
Aaron M. Gibson, Xiufang Pan, Omar Brito-Estrada, James A. Teixeira, Lauren K. Carl, Yongping Yue, Michael L. Kamradt, Matthew J. Burke, Caris A. Wadding-Lee, Gang Yao, Roland W. Herzog, Dongsheng Duan, Catherine A. Makarewich   +12 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

The Regenerative Effect of Various Barrier Membranes With and Without Bone Grafting in Critical Size Defects in Rabbit Calvaria

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objectives This multicentre randomized controlled clinical trial aims to investigate the regenerative effects of various thicknesses and types of barrier materials with and without bone grafting in a rabbit calvaria model. Materials and Methods One hundred male rabbits were partitioned into two groups: one without bone graft (NB) and one with ...
Abdelsalam Elaskary, Rola Al Habashneh, Tasneem Sharairi, Moataz Meabed, Mahmoud Akram Khodir, Ahmed Zaki, Mohammed Alorjani, Bassem Elfahl, Malek Hudieb, Alhassan Diab, Mihad Ibrahim   +10 more
wiley   +1 more source

Quantitative MRI Findings and Their Relationship to Muscle Histopathology and Ambulatory Clinical Function in Duchenne Muscular Dystrophy. [PDF]

J Cachexia Sarcopenia Muscle
Lu Y, Yin L, Liu C, Yuan Q, Xie Z, Liao J, Chen S, Gang Q, Zhao Y, Meng L, Zhang W, Xiao J, Wang Z, Yuan Y, Xie Z.   +14 more
europepmc   +1 more source

Long-term, age-associated activity quantification in the DE50-MD dog model of Duchenne muscular dystrophy

Disease Models & Mechanisms
Kamila Karimjee, Rachel C. M. River, Emil Olsen, Yu-Mei Chang, Dominic J. Wells, Monica A. Daley, Richard J. Piercy   +6 more
doaj   +1 more source

Patient reported outcome measures in spinal muscular atrophy and duchenne muscular dystrophy: review of instruments and their inclusion in clinical and regulatory processes. [PDF]

Neurol Sci
Malandrini F, Spataro C, Meregaglia M, Sansone V, D'amico A, Scopinaro A, Ciani O.   +6 more
europepmc   +1 more source

The Effect of Voxel Volume and Voxel Shape on Cardiac Diffusion Tensor Imaging Metrics

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 2063-2077, April 2026.
ABSTRACT Purpose Cardiac diffusion tensor imaging (cDTI) is signal‐to‐noise ratio (SNR)‐limited due to diffusion signal attenuation, long echo times from gradient moment nulling, and moderate myocardial T 2$$ {}_2 $$. Increasing voxel volume improves SNR but reduces spatial sensitivity and introduces physiological bias.
Ariel J. Hannum, Tyler E. Cork, Kawin Setsompop, Daniel B. Ennis   +3 more
wiley   +1 more source