Results 41 to 50 of about 523,729 (266)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exploration of natural cryoprotectants for cryopreservation of African catfish, Clarias gariepinus, Burchell 1822 (Pisces: Clariidae) spermatozoa

Czech Journal of Animal Science, 2015
Toxicity is a major limitation to successful spermatozoa cryopreservation of fish. Due to this problem, it is critical to find potential cryoprotectants which are more environmental-friendly, non-toxic, easily prepared, and available at affordable prices.
Z.A. Muchlisin, W.N. Nadiah, N. Nadiya, N. Fadli, A. Hendri, M. Khalil, M.N. Siti-Azizah   +6 more
doaj   +1 more source

N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production

JOR Spine, 2022
Background Cell therapy is considered a promising strategy for intervertebral disc (IVD) regeneration. However, cell products often require long‐term cryopreservation, which compromises cell viability and potency, thus potentially hindering ...
Shota Tamagawa, Daisuke Sakai, Jordy Schol, Kosuke Sako, Yoshihiko Nakamura, Erika Matsushita, Takayuki Warita, Soma Hazuki, Hidetoshi Nojiri, Masato Sato, Muneaki Ishijima, Masahiko Watanabe   +11 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Sulphur compounds, methane, and phytoplankton: interactions along a north–south transit in the western Pacific Ocean [PDF]

Biogeosciences, 2013
Here we present results of the first comprehensive study of sulphur compounds and methane in the oligotrophic tropical western Pacific Ocean. The concentrations of dimethylsuphide (DMS), dimethylsulphoniopropionate (DMSP), dimethylsulphoxide (DMSO), and ...
C. Zindler, A. Bracher, C. A. Marandino, B. Taylor, E. Torrecilla, A. Kock, H. W. Bange   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of perphenazine and prochlorperazine on viability of human astrocytes

Annales Academiae Medicae Silesiensis
Phenothiazine derivatives are well-known anti-psychotic drugs that possess several biological activities including anticancer activity. Much research provides data about its anticancer activity against human glioblastoma cell lines.
Michał Otręba, Anna Rzepecka-Stojko, Jerzy Stojko, Agata Kabała-Dzik, Anna Kleczka   +4 more
doaj   +1 more source

UV-B induced alteration of oxygen evolving reactions in pea thylakoid membranes as affected by scavengers of reactive oxygen species

Biologia Plantarum, 2014
The effect of UV-B irradiation at temperatures of 22 and 4 °C on flash induced oxygen yields, photochemical activity, and energy transfer in pea thylakoid membranes in the absence and presence of scavengers of reactive oxygen species (ROS) was studied ...
D. Lazarova, D. Stanoeva, A. Popova, D. Vasilev, M. Velitchkova   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Criopreservación de la cepa RH de Toxoplasma gondii utilizando como criopreservante DMSO y glicerol

Revista Científica Ciencias de la Salud, 2019
El trabajo tuvo como objetivo evaluar la viabilidad de parásitosde Toxoplasma gondiide la cepa RH criopreservados en nitrógeno líquido durante 1 y 5 meses con dos criopreservantes: el glicerol 10% y dimetilsulfóxido (DMSO) 1,25%, 12,5% y 25%,
Carmen Ozuna, Alejandra Rojas, Laura Arias, Teresa Meza, Ivalena Guillén, María Eugenia Acosta   +5 more
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