Results 61 to 70 of about 603,154 (305)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Non-ideal behaviour and solution interactions in binary DMSO solutions

, 2015
The structure and dynamics of hydrogen-bonded structures are of significant importance in understanding many binary mixtures. Since self-diffusion is very sensitive to changes in the molecular weight and shape of the diffusing species, hydrogen- bonded ...
Virk, Amninder (S30184), Codling, Dale J. (S26224), Timothy Stait‐Gardner, Amninder S. Virk, William S. Price, Price, William S. (R10381), Dale J. Codling, Stait-Gardner, Timothy J. (R11775)   +7 more
core   +1 more source

On the structures and properties of Cr(DMSO)(6)(3+) and the coordination polymer cis-Cr(III)(oxalate)(2)(DMSO)(2) K(DMSO)(2) (n)

, 2000
cis-Cr(III)(oxalate)(2)(DMSO)(2)K(DMSO)(2) was formed by K3Cr(oxalate), in dimethylsulfoxide-THF mixtures. The structure is ribbon-like with cis-Cr(oxalate)(2)(DMSO)(2)(-) complex ions bridged by oxalates to (DMSO)K(DMSO)(2)K(DMSO) units forming ...
Svensson, G\uf6ran, 6hrstr\uf6m, Lars
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

DMSO no stim

, 2023
Example images for DMSO-treated neurons ...
Shigeki Watanabe (9106865)
core   +1 more source

UV-B induced alteration of oxygen evolving reactions in pea thylakoid membranes as affected by scavengers of reactive oxygen species

Biologia Plantarum, 2014
The effect of UV-B irradiation at temperatures of 22 and 4 °C on flash induced oxygen yields, photochemical activity, and energy transfer in pea thylakoid membranes in the absence and presence of scavengers of reactive oxygen species (ROS) was studied ...
D. Lazarova, D. Stanoeva, A. Popova, D. Vasilev, M. Velitchkova   +4 more
doaj   +1 more source

N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production

JOR Spine, 2022
Background Cell therapy is considered a promising strategy for intervertebral disc (IVD) regeneration. However, cell products often require long‐term cryopreservation, which compromises cell viability and potency, thus potentially hindering ...
Shota Tamagawa, Daisuke Sakai, Jordy Schol, Kosuke Sako, Yoshihiko Nakamura, Erika Matsushita, Takayuki Warita, Soma Hazuki, Hidetoshi Nojiri, Masato Sato, Muneaki Ishijima, Masahiko Watanabe   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Criopreservación de la cepa RH de Toxoplasma gondii utilizando como criopreservante DMSO y glicerol

Revista Científica Ciencias de la Salud, 2019
El trabajo tuvo como objetivo evaluar la viabilidad de parásitosde Toxoplasma gondiide la cepa RH criopreservados en nitrógeno líquido durante 1 y 5 meses con dos criopreservantes: el glicerol 10% y dimetilsulfóxido (DMSO) 1,25%, 12,5% y 25%,
Carmen Ozuna, Alejandra Rojas, Laura Arias, Teresa Meza, Ivalena Guillén, María Eugenia Acosta   +5 more
doaj  

Effect of perphenazine and prochlorperazine on viability of human astrocytes

Annales Academiae Medicae Silesiensis
Phenothiazine derivatives are well-known anti-psychotic drugs that possess several biological activities including anticancer activity. Much research provides data about its anticancer activity against human glioblastoma cell lines.
Michał Otręba, Anna Rzepecka-Stojko, Jerzy Stojko, Agata Kabała-Dzik, Anna Kleczka   +4 more
doaj   +1 more source