Results 51 to 60 of about 603,154 (305)

cis,cis,cis-Dichloridobis(N4,N4-dimethylpyridin-4-amine-κN1)bis(dimethyl sulfoxide-κS)ruthenium(II)

IUCrData
The structure of the title compound, [RuCl2(C7H10N2)2(C2H6OS)2], has monoclinic (P21/n) symmetry. The Ru—N distances of the coordination compound are influenced by the trans chloride or dimethylsulfoxide-κS ligands.
Esther H. Park, Sarah M. Ortiz, Todd K. Liang, Bradley W. Smucker   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Photophysical parameters of ZnPc-GnRH conjugate in DMSO compared to that of ZnPc in DMSO.

, 2012
Photophysical parameters of ZnPc-GnRH conjugate in DMSO compared to that of ZnPc in DMSO.
Ping Hu (59156), Mingdong Huang (73944), Xueyuan Chen (162951), Peng Xu (17962), Zhuo Chen (135585), Jincan Chen (162945), Shanyong Zhou (162948)   +6 more
core   +1 more source

Диметилсульфоксидные комплексы осмия. Синтез и свойства [H(DMSO)2][OsIII(dmso-S)2Br4]

, 2020
The reaction of H2[OsBr6] with DMSO in ethanol solution resulted in DMSO complex [H(dmso-O)2][OsIII(dmso-S)2Br4] (1) described previously as an intermediate product in the reaction of K2[OsBr6] with DMSO and characterized by EAS and ESR spectra.
DOBROKHOTOVA E.V., OVCHAROV M.V., MININ V.V., KULTYSHKINA E.K., UGOLKOVA E.A., RUDNITSKAYA O.V., EFIMOV N.N.   +6 more
core   +2 more sources

Characterization of DMSO Coordination to Palladium(II) in Solution and Insights into the Aerobic Oxidation Catalyst, Pd(DMSO)₂(TFA)₂

, 2016
Recent studies have shown that Pd­(DMSO)2(TFA)2 (TFA = trifluoroacetate) is an effective catalyst for a number of different aerobic oxidation reactions.
Shannon S. Stahl (1291731), Paul White (431508), Ilia Guzei (2028421), Tianning Diao (1675828)   +3 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

New Cationic and Neutral Ru(II)- and Os(II)-dmso carbonyl Compounds

, 2016
The preparation and structural characterization of three cationic Ru­(II)-dmso carbonyls and of four neutral mono- and dicarbonyl Os­(II)-dmso derivatives is reported.
Gabriele Balducci (1681747), Ioannis Bratsos (1791694), Simone Calmo (1896211), Enzo Alessio (1791688), Ennio Zangrando (543470)   +4 more
core   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Assays for phenotypic and functional characterization of cryopreserved platelets

Platelets, 2019
Platelet concentrates for transfusion have a limited shelf-life, and cryopreservation offers a means of extending platelet shelf-life for at least 2 years. Cryopreservation, however, has some disadvantages, as platelets can be damaged during the freezing
Denese C Marks, Lacey Johnson
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source