Results 171 to 180 of about 202,224 (260)

Snapshots From the Catalytic Landscape of Chalcone Isomerase

Plant Direct, Volume 10, Issue 10, October 2026.
ABSTRACT Chalcone isomerase (CHI) catalyzes the cyclization of three‐ring scaffolds of flavonoids, a class of plant‐based natural products important for nutrition and disease prevention. A persistent question has been whether the enzyme uses protein dynamics to facilitate conformational rearrangements of substrates within the active site.
Jason R. Burke, Matthew A. Rangel, Vanessa I. Vasquez Meza, Hailey N. Mims, Thomas O. Darko, Kelwyn Ixcoy, Alfredo Ruiz Rivera, Jason Zhang, Emma R. Wolf‐Saxon, Chad C. Moorman   +9 more
wiley   +1 more source

Synthesis, Anti‐Leishmania amazonensis Activity, Cytotoxicity, and Molecular Docking of Anthranilate–Naphthoquinone Hybrids

ChemistrySelect, Volume 11, Issue 40, 27 October 2026.
New anthranilate–naphthoquinone hybrids display potent inhibition of Leishmania (L.) amazonensis with low host cell toxicity. Molecular docking reveals key interactions with TR, GP63, and PTR1, suggesting a multitarget mechanism that contributes to parasite death.
Eduardo Miranda da Silva Magesfeste, Lidilhone Hamerski, Diego Mendes Nunes, Ana Paula Sotero da Silva Ribeiro, Elvira Maria Saraiva, Magaly Girão Albuquerque, Camilo Henrique da Silva Lima, Bárbara Vasconcellos da Silva   +7 more
wiley   +1 more source

Molecular mechanisms of simvastatin response in Mesocestoides corti: a proteomic approach to drug repurposing for larval cestodiases. [PDF]

Parasit Vectors
Guedes MM, de Lima JC, Paes JA, Iwai LK, Monteiro KM, Zaha A, Ferreira HB.   +6 more
europepmc   +1 more source

Perspectives for pharmaceutical screening at XFEL sources using the example of Lassa virus endonuclease

Acta Crystallographica Section D, Volume 82, Issue 10, Page 1181-1194, October 2026.
To facilitate structure‐based drug development, XFEL sources are of paramount interest. Here, we analyse the feasibility and data quality of serial femtosecond X‐ray crystallography compound screening at Linac Coherent Light Source and compare it with PETRA III synchrotron experiments.
Sven Falke, Patrick Y. A. Reinke, Daniel Rosenberg, Pontus Fischer, Jan Meyer, Marina Galchenkova, Alexandra Tolstikova, Valerio Mariani, Johanna M. Senst, Philipp Lewe, Susanne Witt, Armin Wagner, Henry N. Chapman, Mark Hunter, Sebastian Günther, Alke Meents   +15 more
wiley   +1 more source

Structure-activity relationship study shows versatility in substrate specificity for heterodisulfide reductase in methanogenic archaea. [PDF]

Protein Sci
Maleki MF, Jakobsen JB, Schuiten ED, Wagner T, Neves ALA, Bunch L.   +5 more
europepmc   +1 more source

Mitochondrial Genetic Background Shapes Baseline Retinal Function, Age‐Related Bioenergetic Remodeling, and Microglial STING Phenotypes

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial Genetic Background Shapes Neuroimmune Aging and Retinal Bioenergetic Remodeling, Authors: McKenna M. Somerville, Sydney S. Lin, Scott W. Ballinger, Alecia K. Gross. This paper uses a mitochondrial‐nuclear exchange mouse model to explore the impact of mitochondrial DNA variation and age on retinal immunometabolism, bioenergetics, and ...
McKenna M. Somerville, Sydney S. Lin, Scott W. Ballinger, Alecia K. Gross   +3 more
wiley   +1 more source

Repurposing the HMG-CoA reductase inhibitor atorvastatin for SRD5A3-congenital disorder of glycosylation. [PDF]

Commun Med (Lond)
Daghar H, Byeon SK, Maios C, Poon J, Doyle J, Ranatunga W, Samarut É, Perlstein EO, Morava E, Pandey A, Parker JA, Kantautas KA.   +11 more
europepmc   +1 more source

FDX1 Depletion Activates CD8+ T Cell Antitumor Immunity by Promoting DMBT1 Secretion in Cuproptosis of Colorectal Cancer

Cancer Science, Volume 117, Issue 10, Page 2659-2675, October 2026.
Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Jieqiong Wu, Zaixi Lian, Mingzhou Li, Xingtu Qin, Xiaoyu Lei, Lihua Yang, Lin Bing, Qiuyue Li, Lingyan Zhou, Zhiyang Ma, Xuemei Xu, Jinghao Huang, Zilong Chen, Lijie Chen, Lingjie Zhang, Zhiyuan Xiao, Xiangyu Jian, Xiaoqin Zhang, Yanqing Ding, Yaping Ye, Li Liang, Hongli Jiao, Shuyang Wang   +22 more
wiley   +1 more source

Elucidating the physiological significance of iodate reduction in <i>Shewanella</i> species. [PDF]

mLife
Wang Z, Hou L, Hu Y, Jiang Z, Dong Y, Shi L, Jiang Y.   +6 more
europepmc   +1 more source

Exploration of Pyrazole‐Sulfonamide Hybrids: Synthesis, Molecular Modeling, Potential Antimicrobial, DHFR Inhibitor, and Pharmacokinetic Profile

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Nine pyrazole‐sulfonamide hybrids 5, 6, and 7 were synthesized and characterized by IR, NMR, and MS. The DFT computations of the built hybrids presented a comparable non‐planar configuration. Comparable HOMO‐LUMO structures were observed, except for the nitro‐derivatives 5c and 6c.
Adhwa A. Alharbi, Manal S. Ebaid, Asmaa L. Alanzy, Adel I. Alalawy, Basma Abbas, Khadra B. Alomari, Roba M. S. Attar, Nashwa M. El‐Metwaly   +7 more
wiley   +1 more source