In psychiatry, the term flashback is widely recognized in relation to post‐traumatic stress disorder (PTSD) as well as in the characterization of post‐psychedelic experiences. Although it is now most commonly associated with PTSD, the term was originally introduced in the context of psychedelics.
Ricarda Evens
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Predictors of initiating high-efficacy vs. platform therapies as first-line disease-modifying treatment in multiple sclerosis. [PDF]
Bin Aziz K +9 more
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Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
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Bead mill-driven acceleration in catalytic methanolysis reaction of poly(ethylene terephthalate) toward low-energy chemical recycling of polymers. [PDF]
Kawase T, Ishitani H, Kobayashi S.
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The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi +4 more
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Deep gray matter atrophy mediates the associations between glymphatic dysfunction and clinical disability in relapsing-remitting multiple sclerosis: a neuroimaging subgroup study. [PDF]
Zhang H +11 more
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ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic +6 more
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Bridging therapy versus direct mechanical thrombectomy in acute ischemic stroke: an updated meta-analysis of real-world evidence. [PDF]
Huang Y, Wang X, Sheng G, Miao X.
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Structural and Mechanical Dynamics of Polymer Membranes Across Multilength Scales
Distinct surface‐to‐bulk mechanical contrasts in polymer membranes were unveiled, highlighting the need to probe both regions to fully capture their functional behavior. By integrating in situ SAXS–WAXS with AFM‐based nanomechanics, nanodomain‐level heterogeneity and real‐time structural transformations induced by thermal and mechanical stimuli were ...
Rifan Hardian +6 more
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