Results 11 to 20 of about 33,443 (169)
Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery
Nature Communications, 2023 Bacteria can exchange DNA through extracellular appendages (‘mating pili’) in a process known as conjugation. Here, Beltran et al. determine atomic structures by cryo-electron microscopy of a bacterial conjugative pilus and two archaeal pili, showing ...
Leticia C. Beltran +11 more
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Frontiers in Microbiology, 2020 Archaeal species encode a variety of distinct lineage-specific chromosomal proteins. We have previously shown that in Thermococcus kodakarensis, histone, Alba, and TrmBL2 play distinct roles in chromosome organization.
Hugo Maruyama +7 more
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DNA replication: archaeal oriGINS
BMC Biology, 2011 GINS is an essential eukaryotic DNA replication factor that is found in a simplified form in Archaea. A new study in this issue of BMC Biology reveals the first structure of the archaeal GINS complex.
Bell Stephen D
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The replication machinery of LUCA: common origin of DNA replication and transcription
BMC Biology, 2020 Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of
Eugene V. Koonin +3 more
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Crystal structures of ternary complexes of archaeal B-family DNA polymerases. [PDF]
PLoS ONE, 2017 Archaeal B-family polymerases drive biotechnology by accepting a wide substrate range of chemically modified nucleotides. By now no structural data for archaeal B-family DNA polymerases in a closed, ternary complex are available, which would be the basis
Heike M Kropp +4 more
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Frontiers in Microbiology, 2021 Histone proteins compact and organize DNA resulting in a dynamic chromatin architecture impacting DNA accessibility and ultimately gene expression. Eukaryotic chromatin landscapes are structured through histone protein variants, epigenetic marks, the ...
Travis J. Sanders +8 more
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Affinity Purification of an Archaeal DNA Replication Protein Network
mBio, 2010 Nineteen Thermococcus kodakarensis strains have been constructed, each of which synthesizes a different His6-tagged protein known or predicted to be a component of the archaeal DNA replication machinery.
Zhuo Li +4 more
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Archaea: A Gold Mine for Topoisomerase Diversity
Frontiers in Microbiology, 2021 The control of DNA topology is a prerequisite for all the DNA transactions such as DNA replication, repair, recombination, and transcription. This global control is carried out by essential enzymes, named DNA-topoisomerases, that are mandatory for the ...
Florence Garnier +6 more
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Archaea Symbiont of T. cruzi Infection May Explain Heart Failure in Chagas Disease
Frontiers in Cellular and Infection Microbiology, 2018 Background: Archaeal genes present in Trypanosoma cruzi may represent symbionts that would explain development of heart failure in 30% of Chagas disease patients. Extracellular vesicles in peripheral blood, called exosomes (< 0.1 μm) or microvesicles (
Maria de Lourdes Higuchi +10 more
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Nature Communications, 2022 DNA primases initiate a short primer before handing off to DNA polymerases to continue replication. Here the authors reveal a unique ability of archaeal primases to first synthesize RNA before stochastically incorporating a deoxyribonucleotide and ...
Mark D. Greci +2 more
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