Results 241 to 250 of about 3,049,090 (315)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Human histone fragments display antibacterial properties against <i>Pseudomonas aeruginosa</i>. [PDF]

Front Immunol
Jaber N, Di Somma A, Rodríguez Alfonso AA, Cané C, Read C, Ständker L, Wiese S, Duilio A, Münch J, Spellerberg B.   +9 more
europepmc   +1 more source

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

Advanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song, Yuting Wang, Zhaolun Wang, Shunji Zhang, Zhengmin Tang, Yongcheng Wang   +5 more
wiley   +1 more source

Bacterial Lysis Observation Over Time Assay (BLOTS) for High-Throughput Isolation, Sequencing, and Characterization of Bacteriophages. [PDF]

Curr Protoc
Pang SJL, Wee SK, Lee BGW, Yap O, Yap EPH.   +4 more
europepmc   +1 more source

Sphingolipids associate with the chlamydial nucleoid and mark developmental transitions in Chlamydia trachomatis. [PDF]

Nat Commun
Rühling M, Wagner F, Epprecht T, Köhling PF, Schumacher F, Sachs S, Kersting L, Fink J, Girndt L, Kleuser B, Sauer M, Seibel J, Weiss GL, Rudel T.   +13 more
europepmc   +1 more source

Interfacial mild alkalinity shapes Neutrophil immunometabolism through sphingolipid remodeling to enhance antibacterial host defense. [PDF]

Mater Today Bio
Zheng G, Li D, Zheng D, Liu Y, He Y, Jiang J, Zhang D, Zhang X, Tong L, Peng F, Yu X, Li M.   +11 more
europepmc   +1 more source

Microbiome-Epigenome Interplay Impacts Microbial Symbiosis and Stress Adaptations in the Brown Planthopper (<i>Nilaparvata lugens</i>). [PDF]

Int J Mol Sci
Gupta A, Nair S.
europepmc   +1 more source