Results 61 to 70 of about 1,207,187 (236)

Modeling Bacterial DNA: Simulation of Self-avoiding Supercoiled Worm-Like Chains Including Structural Transitions of the Helix

, 2017
Under supercoiling constraints, naked DNA, such as a large part of bacterial DNA, folds into braided structures called plectonemes. The double-helix can also undergo local structural transitions, leading to the formation of denaturation bubbles and other
A Laio, A Rich, AV Vologodskii, AV Vologodskii, AV Vologodskii, C Matek, CJ Benham, FC Oberstrass, H Meng, J SantaLucia, JA Gebe, JF Marko, JF Marko, JW Alexander, K Klenin, K Klenin, M Manghi, M Newman, M Thanbichler, MC Lagomarsino, MY Sheinin, N Blot, N Metropolis, P Carrivain, PG Wu, R Vlijm, SM Mirkin, T Lepage, T Strick, TR Strick, VV Rybenkov, Z Bryant, Z Liu   +32 more
core   +1 more source

Substrate-specific clades of active marine methylotrophs associated with a phytoplankton bloom in a temperate coastal environment [PDF]

, 2008
Marine microorganisms that consume one-carbon (C1) compounds are poorly described, despite their impact on global climate via an influence on aquatic and atmospheric chemistry.
Boden, Rich, Moussard, Hélène, Murrell, J. C. (J. Colin), Neufeld, Josh D., Schäfer, Hendrik   +4 more
core   +2 more sources

High Sensitivity of Shotgun Metagenomic Sequencing in Colon Tissue Biopsy by Host DNA Depletion

Genomics, Proteomics & Bioinformatics, 2023
The high host genetic background of tissue biopsies hinders the application of shotgun metagenomic sequencing in characterizing the tissue microbiota. We proposed an optimized method that removed host DNA from colon biopsies and examined the effect on ...
Wing Yin Cheng, Wei-Xin Liu, Yanqiang Ding, Guoping Wang, Yu Shi, Eagle S.H. Chu, Sunny Wong, Joseph J.Y. Sung, Jun Yu   +8 more
doaj  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Oral bacterial DNA findings in pericardial fluid

Journal of Oral Microbiology, 2014
Background: We recently reported that large amounts of oral bacterial DNA can be found in thrombus aspirates of myocardial infarction patients. Some case reports describe bacterial findings in pericardial fluid, mostly done with conventional culturing ...
Anne-Mari Louhelainen, Joonas Aho, Sari Tuomisto, Janne Aittoniemi, Risto Vuento, Pekka J. Karhunen, Tanja Pessi   +6 more
doaj   +1 more source

Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Bacterial translocation is a frequent event in cirrhosis leading to an increased inflammatory response. Splanchnic adrenergic system hyperactivation has been related with increased bacterial translocation. We aim at evaluating the interacting
Pedro Zapater, Isabel Gómez-Hurtado, Gloria Peiró, José Manuel González-Navajas, Irma García, Paula Giménez, Alba Moratalla, José Such, Rubén Francés   +8 more
doaj   +1 more source

Benchmarking microbial DNA enrichment protocols from human intestinal biopsies

Frontiers in Genetics, 2023
Shotgun metagenomic sequencing is a powerful tool for studying bacterial communities in their natural habitats or sites of infection, without the need for cultivation.
Dmitrij Marchukov, Jiaqi Li, Jiaqi Li, Pascal Juillerat, Pascal Juillerat, Pascal Juillerat, Benjamin Misselwitz, Benjamin Misselwitz, Bahtiyar Yilmaz, Bahtiyar Yilmaz   +9 more
doaj   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Detection of airborne Campylobacter with three bioaerosol samplers for alarming bacteria transmission in broilers. [PDF]

, 2011
In an airborne transmission experiment, Campylobacter in the air was sampled by three types of bioaerosol samplers (all-glass impinger AGI-30, Andersen six-stage impactor, and OMNI-3000) in four broiler rooms.
Aarnink, A.J.A., Groot Koerkamp, P.W.G., Hagenaars, T.H.J., Jong, M.C.M., de, Katsma, W.E.A., Zhao, Y.   +5 more
core   +2 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source