Results 91 to 100 of about 2,244,972 (310)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis [PDF]

, 2012
Lsr2 is a small, basic DNA binding protein that is highly conserved in mycobacteria and related actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide ...
Summers, Emma Louise
core  

Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot (Isoodon obesulus) in Western Australia [PDF]

, 2008
The genome of a novel virus, tentatively named bandicoot papillomatosis carcinomatosis virus type 2 (BPCV2), obtained from multicentric papillomatous lesions from an adult male southern brown bandicoot (Isoodon obesulus) was sequenced in its entirety ...
Bennett, M., Nicholls, Philip K., Warren, K., Slaven, Michael, Warren, Kristin S., Van Ranst, Marc, Bennett, M.D., Bennett, Mark D., Woolford, L., Nicholls, P., Woolford, Lucy, Oldfield, T., O'Hara, Amanda J., Nicholls, P.K., Warren, K.S., Slaven, M., Stevens, H., O'Hara, A., Oldfield, Timothy, Stevens, Hans, O'Hara, A.J., Van Ranst, M.   +21 more
core   +1 more source

DNA Ministrings: Highly Safe and Effective Gene Delivery Vectors

Molecular Therapy: Nucleic Acids, 2014
Conventional plasmid DNA vectors play a significant role in gene therapy, but they also have considerable limitations: they can elicit adverse immune responses because of bacterial sequences they contain for maintenance and amplification in prokaryotes ...
Nafiseh Nafissi, Samih Alqawlaq, Eric A Lee, Marianna Foldvari, Paul A Spagnuolo, Roderick A Slavcev   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circular on Deployments, Secondments, Leave of Absence and Transfers in The Public Service [PDF]

Reference is made to the self-explanatory Circular Ref. PSC/ADM/13(60) dated 20th.February 2025 on the above subject (copy attached). In the above referenced Circular, the Public Service Commission (PSC) notes that there have been irregular deployments,
The National Treasury and Economic Planning
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metal complexes as DNA intercalators [PDF]

, 2011
DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research ...
Peter J. Sadler, Hong-Ke Liu, Sadler, P. J., Liu, Hong-Ke   +3 more
core   +1 more source

Multifunctional Bacterial Cellulose Films Incorporating Kratom (Mitragyna speciosa Korth.) Leaf Extract as a Preliminary Antibacterial and Cytocompatible Wound Dressing Candidate

Nanomaterials
Leaves of Mitragyna speciosa Korth. (M. speciosa), commonly known as Kratom, are rich in alkaloids, with mitragynine as the main bioactive compound. This study presents a technique for the entrapment of ethanolic Kratom leaf extract within bacterial ...
Arnon Khamkeaw, Suwaphit Thaksin, Thitiwan Pechsiri, Phasuwit P. Phatchayawat, Suchada Sukrong, Suttinun Phongtamrug, Muenduen Phisalaphong   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source