Results 61 to 70 of about 3,017,680 (323)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells.

Proceedings of the National Academy of Sciences of the United States of America, 1972
The frequency, composition, and structure of circular replicating forms of mitochondrial DNA, including two new forms described here, suggest a scheme for the mode of replication of this DNA.
D. Robberson, H. Kasamatsu, J. Vinograd
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Circular DNA in Isolated Chromoplasts

Zeitschrift für Naturforschung C, 1974
Abstract Flower chromoplasts of Narcissus pseudonarcissus have been isolated in high purity and inte­ grity by a new procedure. From these chromoplasts circular DNA molecules in supercoiled form have been isolated and demonstrated by electron microscopy to have a contour length of about 44 μm (molecular weight about 92 x 106 daltons)
Peter Sitte, Heinz Falk, Bodo Liedvogel
openaire   +3 more sources

Conformation of Circular DNA in 2 Dimensions

, 2008
The conformation of circular DNA molecules of various lengths adsorbed in a 2D conformation on a mica surface is studied. The results confirm the conjecture that the critical exponent $\nu$ is topologically invariant and equal to the SAW value (in the ...
A. D. Bates, Giovanni Dietler, Guillaume Witz, Jozef Adamcik, Kristian Rechendorff, P. G. de Gennes   +5 more
core   +1 more source

Mitochondrial DNA replication in sea urchin oocytes [PDF]

, 1974
Mitochondrial DNA (mtDNA) replicative intermediates from Strongylocentrotus purpuratus oocytes were isolated by ethidium bromide-CsCl density gradient centrifugation and examined by electron microscopy after formamide spreading.
Kasamatsu, Harumi, Matsumoto, Lloyd, Pikó, Lajos, Vinograd, Jerome   +3 more
core   +2 more sources

Topoisomerase 2 is dispensable for the replication and segregation of small yeast artificial chromosomes (YACs). [PDF]

PLoS ONE, 2014
DNA topoisomerases are thought to play a critical role in transcription, replication and recombination as well as in the condensation and segregation of sister duplexes during cell division.
Jorge Cebrián, Estefanía Monturus, María-Luisa Martínez-Robles, Pablo Hernández, Dora B Krimer, Jorge B Schvartzman   +5 more
doaj   +1 more source

Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA

Nucleic Acids Research, 2019
Extrachromosomal circular DNA (eccDNA) is both a driver of eukaryotic genome instability and a product of programmed genome rearrangements, but its extent had not been surveyed in Oxytricha, a ciliate with elaborate DNA elimination and translocation ...
V. T. Yerlici, V. T. Yerlici, Michael W. Lu, Carla Hoge, Richard Miller, Richard Miller, Rafik Neme, Jaspreet S. Khurana, J. Bracht, L. Landweber   +9 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Circular Dichroism of DNA Frayed Wires [PDF]

Biophysical Journal, 1998
Ultraviolet circular dichroism spectra are reported for the oligonucleotide d(A15G15) in aqueous solutions containing 5 mM MgCl2 at several temperatures and in the presence of partially complementary oligonucleotides. Oligonucleotides with several consecutive terminal guanine residues self-associate to form aggregates, called frayed wires, that consist
Robert B. Macgregor, Ekaterina Protozanova   +1 more
openaire   +3 more sources