Results 31 to 40 of about 13,167 (137)
Impairment of hepato‐intestinal homeostasis triggered by ST2 deficiency during T. cruzi infection. Within the splenic compartment, immune dysregulation is marked by a robust pro‐inflammatory polarization of the T‐cell landscape. In the liver, ST2 deficiency is associated with hepatocellular injury, increased parasite burden, and hyperalbuminemia ...
Marcelo Eduardo Cardozo +22 more
wiley +1 more source
Quantitative Polymerase Chain Reaction for Diagnosis of Soil-Transmitted Helminth Infections: A Comparison with a Flotation-Based Technique and an Investigation of Variability in DNA Detection [PDF]
Appropriate diagnostic techniques are crucial to global soil-transmitted helminth (STH) control efforts. The recommended Kato–Katz method has low sensitivity in low-transmission settings. Quantitative polymerase chain reaction (qPCR) is a highly sensitive alternative diagnostic option. However, little is known about the variability in qPCR results, and
Clarke, Naomi +5 more
openaire +5 more sources
Synthetic Ligands of Myeloid C‐Type Lectin Receptors
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley +1 more source
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
wiley +1 more source
What Is Your Diagnosis? Esophageal and Gastric Washes in a Pet Moellendorff's Rat Snake
Veterinary Clinical Pathology, EarlyView.
Lina C. Bilhalva +5 more
wiley +1 more source
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther +13 more
wiley +1 more source
Using 18S rDNA metabarcoding of stomach contents from two Antarctic nototheniid fishes, we detected 242 parasite OTUs. Protists dominated diversity, metazoans dominated abundance, and depth structured assemblages. Novel parasite–host associations and previously unreported pathogenic protists highlight fish metabarcoding as a tool for biodiversity and ...
Micaela B. Ruiz +6 more
wiley +1 more source
Immunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM‐, Foxl1‐, Ccl24‐ lamina propria‐resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin
Connor P. Lynch +5 more
wiley +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
Additional file 3: Figures S1-S3. Phylogenetic tree for each genetic marker using maximum likelihood and Bayesian Inference algorithms.
Chan, Abigail Hui En +4 more
openaire +1 more source

