Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice [PDF]
Development of an effective vaccine against malaria remains a priority. However, a significant number of individuals living in tropical areas are also likely to be co-infected with helminths, which are known to adversely affect immune responses to a number of different existing vaccines. Here we compare the response to two prototype malaria vaccines: a
Gregory S, Noland +4 more
openaire +2 more sources
Echinococcus multilocularis coproantigen detection by enzyme-linked immunosorbent assay in fox, dog, and cat populations [PDF]
A sandwich enzyme-linked immunosorbent assay (ELISA) for the detection of Echinococcus multilocularis coproantigens (EM-ELISA) was developed with polyclonal rabbit (solid phase) and chicken egg (catching) antibodies that were directed against E ...
Alther, P. +4 more
core +2 more sources
Infections caused by Schistosoma haematobium and Opisthorchis viverrini are classified as carcinogenic. Although carcinogenesis might be a multifactorial process, it has been postulated that these helminth produce/excrete oxysterols and estrogen-like ...
Maria João Gouveia +4 more
doaj +1 more source
Parasites cause numerous health issues in humans, eventually leading to significant social and economic damage; however, the mechanisms of parasite-mediated pathogenesis are not well understood.
Galina N. Chelomina +3 more
doaj +1 more source
FREEZABILITY, DNA INTEGRITY AND FERTILIZING CAPACITY OF SPERMATOZOA OF FRIESIAN BULLS TREATED WITH ANTI - HELMINTHIC DRUGS [PDF]
Effect of three different anti-helminthic drugs (ivermectin, levamisole and albendazole) on quality and fertility of spermatozoa of frozen-thawed semen of Frisian bulls .Animals were divided into four groups, control untreated group, and bulls treated with 200 µg/kg of ivermectin (IVM), 7.5 mg/kg of levamisole (LEV), and 10 mg/kg of albendazole (ABZ),
M. Tag El-Dein +4 more
openaire +1 more source
Molecular Detection of Helminths in Stool Samples: Methods, Challenges, and Applications
Helminth infections caused by soil-transmitted species, like Ascaris lumbricoides, Trichuris trichiura, and hookworms, affect over one billion people worldwide, yet accurate diagnosis remains challenging due to low sensitivity of microscopy in detecting ...
María M. De Vivero +3 more
doaj +1 more source
A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection [PDF]
Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed to develop a novel non-invasive technique to investigate immunological host responses ...
Affinass, Nicole +8 more
core +4 more sources
Helminth-induced immune modulation in colorectal cancer: exploring therapeutic applications
Colorectal cancer is one of the most lethal tumors, posing a financial and healthcare burden. This study investigates how helminths and pre-existing diseases such as colitis, obesity, diabetes, and gut microbiota issues influence colon cancer development
Hongyu Li +13 more
doaj +1 more source
Anisakis pegreffii impacts differentiation and function of human dendritic cells [PDF]
Human dendritic cells (DCs) show remarkably phenotypic changes when matured in presence of helminth-derived products. These modifications frequently elicited a polarization towards Th2 cells and regulatory T cells thus contributing to immunological ...
Allen +55 more
core +1 more source
Gastrointestinal helminths are major enteric parasites affecting the health of important livestock ruminants, such as cattle and goats. It is important to routinely survey these animals for helminth infections to allow effective management and control ...
Nicharee Income +6 more
doaj +1 more source

