Results 211 to 220 of about 151,067 (292)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

A novel TEAD1::NCOA2 fusion that potentially expands the concept of supratentorial ependymoma, YAP1 fusion-positive. [PDF]

Acta Neuropathol
Tauziède-Espariat A, Appay R, Bouvier C, Testud B, Girard N, Métais A, Servant E, Scavarda D, Meurgey A, Pissaloux D, Hasty L, Varlet P, RENOCLIP-LOC.   +12 more
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

EGFR-KDD Myofibroblastic Neoplasm or Congenital Peribronchial Myofibroblastic Tumor (CPMT)? Report of a Congenital Myofibroblastic Neoplasm With Unusual Histologic Features. [PDF]

Genes Chromosomes Cancer
Rullo E, Barresi S, Rossi S, Patrizi S, Miele E, Barisella M, Casanova M, Ferrari A, Chiaravalli S, Pelizzo G, Alaggio R.   +10 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Deciphering the multifaceted role of <i>EXO1</i> in female-related cancers: implications for prognosis and therapeutic responsiveness. [PDF]

Front Immunol
Yu C, Wu G.
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Spatial proteomics of Onchocerca volvulus with pleomorphic neoplasms shows local and systemic dysregulation of protein expression. [PDF]

PLoS Negl Trop Dis
Di Maggio LS, Fischer K, Rosa BA, Yates D, Cho BK, Lukowski J, Zamacona Calderon A, Son M, Goo YA, Opoku NO, Weil GJ, Mitreva M, Fischer PU.   +12 more
europepmc   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Enhanced Disease Detection of Hairy Cell Leukaemia Through Next-Generation Sequencing Based <i>BRAF</i> ^V600E and Phased Variant Analysis. [PDF]

EJHaem
Wu S, Nguyen T, Caldwell I, Hunter S, Kannan S, Santos C, Yap YZ, Wilson C, Rawicki M, Tam CS, Koldej R, Ritchie D, Blombery P.   +12 more
europepmc   +1 more source