Results 201 to 210 of about 3,320,596 (325)

Recombinant DNA is safe [PDF]

Nature, 1978
openaire   +2 more sources

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

High-throughput conjugation reveals strain specific recombination patterns enabling precise trait mapping in Escherichia coli. [PDF]

PLoS Genet
Corneloup T, Bellengier J, Rosinski-Chupin I, Magnan M, Chavan A, Gachet B, Dixit Z, Pintard C, Baron A, Toko D, Lambert A, Choudhury A, Tenaillon O.   +12 more
europepmc   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

One IV HEDGES DNA vector administration encoding hGLA or hGH produces durable hGLA and hGH serum lvels in immunocompetent mice. [PDF]

PLoS One
Ye A, Mack M, Ursu S, Chmura S, Steiner R, Heath T, Handumrongkul C, Debs R.   +7 more
europepmc   +1 more source

Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

Nature Medicine, 2003
S. McConkey, W. Reece, V. Moorthy, D. Webster, Susanna J. Dunachie, G. Butcher, J. Vuola, T. Blanchard, P. Gothard, K. Watkins, C. Hannan, S. Everaere, K. Brown, K. Kester, J. Cummings, Jackie Williams, D. Heppner, A. Pathan, K. Flanagan, N. Arulanantham, M. Roberts, M. Roy, Geoffrey L. Smith, J. Schneider, T. Peto, R. Sinden, S. Gilbert, A. Hill   +27 more
semanticscholar   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

Improving the diagnosis of cassava mosaic begomoviruses using Oxford Nanopore Technology sequencing. [PDF]

Sci Rep
Combala M, Tibiri EB, Pita JS, Eni AO, Sawadogo S, Name PE, Zongo S, Kouhoumouri P, Sagnon A, Efekemo OP, Onile-Ere O, Oppong A, Ndougonna C, Tiendrébéogo F.   +13 more
europepmc   +1 more source

TOPALi: software for automatic identification of recombinant sequences within DNA multiple alignments

Bioinform., 2004
Iain Milne, F. Wright, Glenn Rowe, D. Marshall, D. Husmeier, G. McGuire   +5 more
semanticscholar   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source