Results 191 to 200 of about 602,797 (262)

Research note: Development of a recombinant duck enteritis virus vector expressing DHAV-3 VP1 and DTMUV prM/TE genes. [PDF]

Poult Sci
Jia W, Wu Z, Tan A, Cheng Y, Zhou Q, Zhu S, Wang A.   +6 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

IL-32 drives PR3-dependent NET formation to promote portal vein tumor thrombosis and radioresistance in HCC. [PDF]

Transl Oncol
Yao L, Pan Y, Shi G, Kang P, Luan S, Leng K.   +5 more
europepmc   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Evaluation of immune protective efficacy of recombinant subunit vaccines based on Eimeria tenella EtAMA1 and EtSAG13. [PDF]

Poult Sci
Zhu S, Wang H, Liu Y, Gao H, Lv C, Kang S, Cui X, Lv X, Li J, Bai R.   +9 more
europepmc   +1 more source

Pilot-Scale Downstream Processing of Recombinant Influenza Virus Vectors Expressing <i>Brucella</i> spp. Antigens Using an Integrated Membrane-Chromatography Purification Platform. [PDF]

Vaccines (Basel)
Assanzhanova N, Sagymbayeva A, Shynybekova G, Shorayeva K, Ryskeldinova S, Mailybayeva A, Myrzakhmetov Y, Yamanova E, Sidikhov R, Almezhanova M, Zhaksylyk S, Absatova Z, Zhugunissov K, Chervyakova O, Akmyrzayev N.   +14 more
europepmc   +1 more source

Rapid on-site detection of Pasteurella multocida in cattle using an LFS-based RPA-CRISPR/Cas12a assay. [PDF]

Ir Vet J
Han X, Wang R, Ni Y, Sun Z, Jin Y, Xing Z, Guo Y, Wang H, Liu S, Diao Y, Liu H, Chi L.   +11 more
europepmc   +1 more source

Development and Preliminary Field Evaluation of an Indirect ELISA for Detecting Tomato Yellow Leaf Curl Virus. [PDF]

Viruses
Zhang Z, Liu Y, Zhang X, Xue X, Xu T.
europepmc   +1 more source