Results 171 to 180 of about 614,049 (312)

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Recombinant DNA Advisory Committee: minutes of meeting September 19-20, 2002 [PDF]

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

Practical guidelines for producing non-replicating canine adenovirus vectors. [PDF]

PLoS One
Omara D, Ndekezi C, Mugaba S, Nakyanzi A, Bukenya H, Bwogi J, Natwijuka F, Kapaata A, Kato F, Byamukama D, Ayebale ML, Kateete DP, Serwanga J, Cose S, Obondo SJ, Kaleebu P, Balinda SN.   +16 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Recombinant DNA Advisory Committee: minutes of meeting December 4-6, 2002 [PDF]

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

Development of canine parvovirus-2-based recombinant pseudoviruses expression system: a potential vaccine platform. [PDF]

Vet Res
Miao B, Du Q, Yang L, Yan J, Tu F, Jiang Y, Xu N, Chen S, Huang Y, Tong D.   +9 more
europepmc   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Recombinant DNA Advisory Committee (RAC): meeting agenda December 4-6, 2002 [PDF]

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

Protective Immunity Induced by DNA Vaccines Encoding TgGRA47 and TgGRA72 Against <i>Toxoplasma gondii</i> Infection in BALB/c Mice. [PDF]

Transbound Emerg Dis
Zhou Z, Mu J, Sun J, Chen J, Zhou C.
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source