Results 161 to 170 of about 611,894 (312)

A designed peptide disrupting viral protease cleavage restores cGAS-DNA phase separation and type I interferon responses. [PDF]

PLoS Pathog
Yin H, Zhao Z, Wang H, Li X.
europepmc   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Development of canine parvovirus-2-based recombinant pseudoviruses expression system: a potential vaccine platform. [PDF]

Vet Res
Miao B, Du Q, Yang L, Yan J, Tu F, Jiang Y, Xu N, Chen S, Huang Y, Tong D.   +9 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Protective Immunity Induced by DNA Vaccines Encoding TgGRA47 and TgGRA72 Against <i>Toxoplasma gondii</i> Infection in BALB/c Mice. [PDF]

Transbound Emerg Dis
Zhou Z, Mu J, Sun J, Chen J, Zhou C.
europepmc   +1 more source

Recombinant DNA Advisory Committee (minutes of meeting, 3 October 1988)

, 1988
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee
core  

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Practical guidelines for producing non-replicating canine adenovirus vectors. [PDF]

PLoS One
Omara D, Ndekezi C, Mugaba S, Nakyanzi A, Bukenya H, Bwogi J, Natwijuka F, Kapaata A, Kato F, Byamukama D, Ayebale ML, Kateete DP, Serwanga J, Cose S, Obondo SJ, Kaleebu P, Balinda SN.   +16 more
europepmc   +1 more source

Recombinant DNA Advisory Committee: minutes of meeting February 10, 2003

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source