Results 161 to 170 of about 614,049 (312)

ADMINISTRATIVE PRACTICES SUPPLEMENT TO THE NIH GUIDELINES FOR RESEARCH INVOLVING RECOMBINANT DNA MOLECULES: POLICIES AND ADMINISTRATIVE PROCEDURES FOR RECOMBINANT DNA RESEARCH SUBJECT TO THE NIH GUIDELINES [PDF]

, 1979
National Institute of General Medical Sciences (United States). Office of Recombinant DNA Activities
core  

CpxR and LrhA coordinate the regulation of Xenocoumacin 1 biosynthesis, flagellar assembly, and chemotaxis in <i>Xenorhabdus nematophila</i>. [PDF]

Front Microbiol
Han Y, Liu H, Zhao X, He M, Chen Y, Li T, Liu J, Zhang S, Tang G, Wang Y.   +9 more
europepmc   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Prenatal Gene Transfer: Scientific, Medical, and Ethical Issues: A Report of the Recombinant DNA Advisory Committee [PDF]

, 2000
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee
core  

A rapid yeast-based reverse genetics system reveals SARS-CoV-2 Omicron BA.2.86 variant spreads faster than Omicron JN.1 variant in primary human nasal and bronchial epithelial airway cultures. [PDF]

mBio
Xu J, Chamblee M, Hsu CC, Jiang F, Chen P, Zhang Y, Liang X, Amer AO, Boyaka PN, Cormet-Boyaka E, Peeples ME, Li J.   +11 more
europepmc   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Recombinant DNA Advisory Committee (RAC): 91st meeting of the NIH RAC [PDF]

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Recombinant DNA Advisory Committee (RAC): meeting agenda September 19-20, 2002 [PDF]

, 2003
National Institutes of Health [NIH] (United States). Recombinant DNA Advisory Committee [RAC]
core  

A designed peptide disrupting viral protease cleavage restores cGAS-DNA phase separation and type I interferon responses. [PDF]

PLoS Pathog
Yin H, Zhao Z, Wang H, Li X.
europepmc   +1 more source