Results 1 to 10 of about 2,640,580 (326)

DNA replication stress restricts ribosomal DNA copy number. [PDF]

PLoS Genetics, 2017
Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus.
Devika Salim, William D Bradford, Amy Freeland, Gillian Cady, Jianmin Wang, Steven C Pruitt, Jennifer L Gerton   +6 more
doaj   +6 more sources

DNA Binding by the Ribosomal DNA Transcription Factor Rrn3 Is Essential for Ribosomal DNA Transcription [PDF]

Journal of Biological Chemistry, 2013
The human homologue of yeast Rrn3 is an RNA polymerase I-associated transcription factor that is essential for ribosomal DNA (rDNA) transcription. The generally accepted model is that Rrn3 functions as a bridge between RNA polymerase I and the transcription factors bound to the committed template. In this model Rrn3 would mediate an interaction between
Ann, Stepanchick, Huijun, Zhi, Alice H, Cavanaugh, Katrina, Rothblum, David A, Schneider, Lawrence I, Rothblum   +5 more
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Characterization of Yeast Ribosomal DNA [PDF]

European Journal of Biochemistry, 1975
High‐molecular‐weight yeast ribosomal DNA, purified by preparative Hg2/Cs2SO4 gradient centrifugation, was characterized using RNA‐DNA hybridization, CsCl gradient analysis and denaturation‐renaturation experiments. The following conclusions are drawn from the results of these studies.
J, Retèl, H, Van Keulen
openaire   +2 more sources

Heterogeneity of Pumpkin Ribosomal DNA [PDF]

Plant Physiology, 1983
The ribosomal DNA (rDNA) of Cucurbita pepo L. has been found to consist of tandemly arrayed repeat units, most of which are 10 kilobases in length. Thirty-six repeat units, cloned into the HindIII site of pACYC 177, fall into seven classes which differ from each other in length and/or nucleotide sequence.
A, Siegel, K, Kolacz
openaire   +2 more sources

Ribosomal DNA heterochromatin in plants [PDF]

Cytogenetic and Genome Research, 2005
The aim of this review is to integrate earlier results and recent findings to present the current state-of-the-art vision concerning the dynamic behavior of the ribosomal DNA (rDNA) fraction in plants. The global organization and behavioral features of rDNA make it a most useful system to analyse the relationship between chromatin topology and gene ...
Neves, N., Delgado, M., Silva, M., Caperta, A., Morais-Cecilio, L., Viegas, W.   +5 more
openaire   +3 more sources

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Nature Communications, 2020
DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar ...
Clémence Mooser, Ioanna-Eleni Symeonidou, Pia-Amata Leimbacher, Alison Ribeiro, Ann-Marie K. Shorrocks, Stephanie Jungmichel, Sara C. Larsen, Katja Knechtle, Arti Jasrotia, Diana Zurbriggen, Alain Jeanrenaud, Colin Leikauf, Daniel Fink, Michael L. Nielsen, Andrew N. Blackford, Manuel Stucki   +15 more
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DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome

Frontiers in Genetics, 2022
Control of ribosome biogenesis is a critical aspect of the regulation of cell metabolism. As ribosomal genes (rDNA) are organized in repeated clusters on chromosomes 13, 14, 15, 21, and 22, trisomy of chromosome 21 confers an excess of rDNA copies to ...
Francesco Ravaioli, Michele Zampieri, Luca Morandi, Luca Morandi, Chiara Pirazzini, Camilla Pellegrini, Sara De Fanti, Sara De Fanti, Noémie Gensous, Noémie Gensous, Gian Luca Pirazzoli, Luisa Sambati, Alessandro Ghezzo, Fabio Ciccarone, Anna Reale, Daniela Monti, Stefano Salvioli, Paola Caiafa, Miriam Capri, Alexander Bürkle, Maria Moreno-Villanueva, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Paolo Garagnani, Claudio Franceschi, Maria Giulia Bacalini   +26 more
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Ribosomal DNA-connecting ribosome biogenesis and chromosome biology [PDF]

Chromosome Research, 2019
Ribosomal DNA, the topic of this special issue, has long fascinated biologists. The RNA products of the ribosomal DNA are the ribosomal RNAs that are part of the ribosome. In this special issue, we focus on the sequence, molecular organization, repair, stability, copy number, and peculiar genetics of this region of the genome.
Lev, Porokhovnik, Jennifer L, Gerton
openaire   +2 more sources

Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase

BMC Cell Biology, 2003
Background Bloom syndrome is one of the most cancer-predisposing disorders and is characterized by genomic instability and a high frequency of sister chromatid exchange. The disorder is caused by loss of function of a 3' to 5' RecQ DNA helicase, BLM. The
Paric Enesa, Schawalder James, Neff Norma F   +2 more
doaj   +1 more source

Early life stress inhibits expression of ribosomal RNA in the developing hippocampus. [PDF]

PLoS ONE, 2014
Children that are exposed to abuse or neglect show abnormal hippocampal function. However, the developmental mechanisms by which early life stress (ELS) impairs normal hippocampal development have not been elucidated. Here we propose that exposure to ELS
Lan Wei, Jin Hao, Arie Kaffman
doaj   +1 more source