Results 1 to 10 of about 10,709 (124)
DNA replication stress restricts ribosomal DNA copy number. [PDF]
PLoS Genetics, 2017 Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100-200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus.
Devika Salim +6 more
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Ribosomal DNA heterochromatin in plants [PDF]
Cytogenetic and Genome Research, 2005 The aim of this review is to integrate earlier results and recent findings to present the current state-of-the-art vision concerning the dynamic behavior of the ribosomal DNA (rDNA) fraction in plants. The global organization and behavioral features of rDNA make it a most useful system to analyse the relationship between chromatin topology and gene ...
Neves, N. +5 more
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DNA Binding by the Ribosomal DNA Transcription Factor Rrn3 Is Essential for Ribosomal DNA Transcription [PDF]
Journal of Biological Chemistry, 2013 The human homologue of yeast Rrn3 is an RNA polymerase I-associated transcription factor that is essential for ribosomal DNA (rDNA) transcription. The generally accepted model is that Rrn3 functions as a bridge between RNA polymerase I and the transcription factors bound to the committed template. In this model Rrn3 would mediate an interaction between
Ann Stepanchick +5 more
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Organization of the bacterial nucleoid by DNA-bridging proteins and globular crowders [PDF]
Frontiers in Microbiology, 2023, 14, 2023 The genomic DNA of bacteria occupies only a fraction of the cell called the nucleoid, although it is not bounded by any membrane and would occupy a volume hundreds of times larger than the cell in the absence of constraints. The two most important contributions to the compaction of the DNA coil are the cross-linking of the DNA by nucleoid proteins ...
arxiv +1 more source
Characterization of Yeast Ribosomal DNA [PDF]
European Journal of Biochemistry, 1975 High‐molecular‐weight yeast ribosomal DNA, purified by preparative Hg2/Cs2SO4 gradient centrifugation, was characterized using RNA‐DNA hybridization, CsCl gradient analysis and denaturation‐renaturation experiments. The following conclusions are drawn from the results of these studies.
J. Retèl, Harry Van Keulen
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Heterogeneity of Pumpkin Ribosomal DNA [PDF]
Plant Physiology, 1983 The ribosomal DNA (rDNA) of Cucurbita pepo L. has been found to consist of tandemly arrayed repeat units, most of which are 10 kilobases in length. Thirty-six repeat units, cloned into the HindIII site of pACYC 177, fall into seven classes which differ from each other in length and/or nucleotide sequence.
Albert Siegel, Kathryn Kolacz
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Dynamics of ribosomes in mRNA translation under steady and non-steady state conditions [PDF]
Phys. Rev. E 101, 062404 (2020), 2020 Recent advances in DNA sequencing and fluorescence imaging have made it possible to monitor the dynamics of ribosomes actively engaged in messenger RNA (mRNA) translation. Here, we model these experiments within the inhomogeneous totally asymmetric simple exclusion process (TASEP) using realistic kinetic parameters.
arxiv +1 more source
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
Nature Communications, 2020 DNA double-strand breaks in ribosomal DNA repeats is associated with repression of ribosomal RNA synthesis. Here the authors reveal a cooperation between TOPBP1 and Treacle in the signaling cascade that triggers transcriptional inhibition and nucleolar ...
Clémence Mooser +15 more
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DNA Methylation Analysis of Ribosomal DNA in Adults With Down Syndrome
Frontiers in Genetics, 2022 Control of ribosome biogenesis is a critical aspect of the regulation of cell metabolism. As ribosomal genes (rDNA) are organized in repeated clusters on chromosomes 13, 14, 15, 21, and 22, trisomy of chromosome 21 confers an excess of rDNA copies to ...
Francesco Ravaioli +26 more
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Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase
BMC Cell Biology, 2003 Background Bloom syndrome is one of the most cancer-predisposing disorders and is characterized by genomic instability and a high frequency of sister chromatid exchange. The disorder is caused by loss of function of a 3' to 5' RecQ DNA helicase, BLM. The
Paric Enesa +2 more
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