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From Mutation to Degradation: Predicting Nonsense-Mediated Decay with NMDEP [PDF]
Nonsense-mediated mRNA decay (NMD) is a critical post-transcriptional surveillance mechanism that degrades transcripts with premature termination codons, safeguarding transcriptome integrity and shaping disease phenotypes. However, accurately predicting NMD efficiency remains challenging, as existing models often rely on simplistic rule-based ...
arxiv
THE IN VITRO FORMATION OF A DNA-RIBOSOME COMPLEX [PDF]
H. A. Bladen+3 more
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The primary ribosomal DNA transcript in eukaryotes
D. Rungger, M. Crippa
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Characterization of Longidorus caespiticola (Nematoda: Longidoridae) from the Czech Republic
Kumari S.
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Ribosomal DNA in the Rat [PDF]
THE amount of DNA complementary to ribosomal RNA (rDNA) has been shown to be constant in several tissues varying in rRNA synthesis1,2. There is, however, a dramatic exception to this in amphibian and insect oocytes3–5, where amplification of the rDNA occurs and results in high rates of rRNA synthesis during oogenesis6.
Adrian Dunn, Luigi Casola, Jag Mohan
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Ribosomal DNA and the nucleolus at the heart of aging
Trends in Biochemical Sciences, 2022The rRNA genes [ribosomal DNA (rDNA)] are organized in a prominent nuclear compartment, the nucleolus. It is now well established that the nucleolus functions beyond ribosome biosynthesis, regulating several physiological cellular responses. The nucleoli constitute dynamic genomic/nuclear hubs and demonstrate unique inherent characteristics, rendering ...
Kasselimi, Eirini+3 more
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Circular ribosomal DNA and ribosomal DNA: replication in somatic amphibian cells
Chromosoma, 1975Pulse labelled rDNA from cultured somatic cells of Xenopus laevis was examined by electron microscope autoradiography. The pattern of replication closely resembles that of bulk chromosomal DNA and differs considerably from rDNA synthesis during amplification in the oocyte.
Jean-David Rochaix+2 more
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The Ribosomal DNA Plasmids of Entamoeba
Parasitology Today, 1998In most organisms, the nuclear ribosomal RNA (rRNA) genes are highly repetitive and arranged as tandem repeats on one or more chromosomes. In Entamoeba, however, these genes are located almost exclusively on extrachromosomal circular DNA molecules with no clear evidence so far of a chromosomal copy.
Sudha Bhattacharya+2 more
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Structure and organization of ribosomal DNA
Biochimie, 1991Three trends are seen in the organization of ribosomal DNA genes during evolution: 1) gradual separation and separability of the regulation of transcription of 5S and larger subunit rRNAs; 2) retention of a transcription unit containing both large and small rRNAs; and 3) clustering of genes for both 5S and 18S-28S rDNAs, with the possible association ...
D. Schlessinger, A.K. Srivastava
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Heterogeneity in cucumber ribosomal DNA
Theoretical and Applied Genetics, 1986Restriction and hybridization analysis of cucumber native ribosomal (r) DNA purified from actinomycin-D/CsCl gradients suggested that the repeat units were heterogeneous in both length and sequence. Several full length rDNA repeat units were cloned and five are described which account for all the EcoR I and Xba I fragments present in native DNA. One of
T. A. Kavanagh, J. N. Timmis
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